{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:27:15Z","timestamp":1761863235557},"reference-count":0,"publisher":"American Diabetes Association","issue":"10","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,10,1]]},"abstract":"<jats:p>Approximately 50% of Wistar \u201cBB\u201d rats spontaneously develop overt diabetes mellitus characterized by loss of \u03b2-cells and \u201cinsulitis.\u201d To define abnormalities of immunoregulation in these rats, we quantitated their major circulating lymphocyte subsets. Independent of the development of diabetes, we found the BB rats to have a markedly increased percentage of circulating B lymphocytes which is secondary to a severe T-cell lymphocytopenia, with the major circulating T-cell subset reacting with monoclonal antibody W3\/25 markedlydecreased. This lymphocytopenia is present in every animal studied and contrasted with studies of the nondiabetic Wistar strain from which the \u201cBB\u201d rats were developed.<\/jats:p>","DOI":"10.2337\/diab.30.10.887","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"887-889","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":81,"title":["The BB Diabetic Rat: Profound T-Cell Lymphocytopenia"],"prefix":"10.2337","volume":"30","author":[{"given":"R","family":"Jackson","sequence":"first","affiliation":[{"name":"Divisions of Endocrinology and Rheumatology, Department of Medicine and Physiology, Duke University Medical Center\u2008Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Rassi","sequence":"additional","affiliation":[{"name":"Divisions of Endocrinology and Rheumatology, Department of Medicine and Physiology, Duke University Medical Center\u2008Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Crump","sequence":"additional","affiliation":[{"name":"Divisions of Endocrinology and Rheumatology, Department of Medicine and Physiology, Duke University Medical Center\u2008Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Haynes","sequence":"additional","affiliation":[{"name":"Divisions of Endocrinology and Rheumatology, Department of Medicine and Physiology, Duke University Medical Center\u2008Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G S","family":"Eisenbarth","sequence":"additional","affiliation":[{"name":"Divisions of Endocrinology and Rheumatology, Department of Medicine and Physiology, Duke University Medical Center\u2008Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/30\/10\/887\/351510\/30-10-887.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/30\/10\/887\/351510\/30-10-887.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:35:47Z","timestamp":1667406947000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/30\/10\/887\/5180\/The-BB-Diabetic-Rat-Profound-T-Cell"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1981,10,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.30.10.887","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,10,1]]}}}