{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:47:21Z","timestamp":1790660841092,"version":"4.1.0"},"reference-count":0,"publisher":"American Diabetes Association","issue":"12","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,12,1]]},"abstract":"<jats:p>The fa-gene was transferred from the Zucker rat (13 M strain) to the Wistar Kyoto (WKY) rat. The survey, performed at the 10th generation of backcrossing, showed that Wistar fatty rats (fa\/fa), a congenic strain of WKY, developed obesity and obesity-related features, such as hyperinsulinemia and hyperlipemia, in the same manner as Zucker fatty rats. Males, but not females, showed hyperglycemia, glucosuria, and polyuria as early as 8 wk of age. Tolerance and insulin response to oral glucose were decreased with advancing age in males.<\/jats:p>\n               <jats:p>The diabetic changes appeared to be caused by an interaction between predisposition to develop diabetes in the WKY rat and fa-induced obesity. This is because WKY rats were found to be less sensitive to insulin than Zucker rats by both the glucose tolerance test and the steady-state blood glucose method which estimates overall insulin sensitivity.<\/jats:p>","DOI":"10.2337\/diab.30.12.1045","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"1045-1050","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":129,"title":["A New Genetically Obese-Hyperglycemic Rat (Wistar Fatty)"],"prefix":"10.2337","volume":"30","author":[{"given":"Hitoshi","family":"Ikeda","sequence":"first","affiliation":[{"name":"Biology Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.\u2008Yodogawa-ku, Osaka 532, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Shino","sequence":"additional","affiliation":[{"name":"Biology Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.\u2008Yodogawa-ku, Osaka 532, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Matsuo","sequence":"additional","affiliation":[{"name":"Biology Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.\u2008Yodogawa-ku, Osaka 532, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Iwatsuka","sequence":"additional","affiliation":[{"name":"Biology Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.\u2008Yodogawa-ku, Osaka 532, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziro","family":"Suzuoki","sequence":"additional","affiliation":[{"name":"Biology Laboratories, Central Research Division, Takeda Chemical Industries, Ltd.\u2008Yodogawa-ku, Osaka 532, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/30\/12\/1045\/351300\/30-12-1045.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/30\/12\/1045\/351300\/30-12-1045.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:35:59Z","timestamp":1667406959000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/30\/12\/1045\/5221\/A-New-Genetically-Obese-Hyperglycemic-Rat-Wistar"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,12,1]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1981,12,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.30.12.1045","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,12,1]]}}}