{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T07:00:48Z","timestamp":1775890848251,"version":"3.50.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"6","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,6,1]]},"abstract":"<jats:p>Glucose clearance (glucose utilization \u00f7 plasma glucose) is commonly used to assess glucose utilization under conditions in which plasma glucose concentrations vary. The validity of this practice requires that glucose clearance itself be independent of plasma glucose concentration. The present studies were, therefore, undertaken to determine the relationship between glucose clearance and plasma glucose concentration in man. Using the glucose clamp technique, rates of glucose utilization (measured isotopically with 3-3H-glucose) and glucose clearance were determined in 5 normal volunteers at steady-state plasma glucose concentrations of approximately 60, 95,130, and 165 mg\/dl, while plasma insulin concentrations were maintained constant (\u223c18 \u03bcU\/ml) by infusion of insulin and somatostatin. Despite virtually identical 0.4 mg \u00b7 kg\u22121 \u00b7 min\u22121 increments in glucose utilization for each 35-mg\/dl increment in plasma glucose, glucose clearance decreased as a function of plasma glucose concentration (r = \u2212 0.85, P &amp;lt; 0.001). These results indicate that glucose clearance is not independent of changes in plasma glucose concentration and, thus, use of glucose clearance to evaluate glucose utilization at differing plasma glucose concentration is not valid. Whether this conclusion also applies to similar use of clearance for other substrates remains to be determined.<\/jats:p>","DOI":"10.2337\/diab.30.6.535","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"535-537","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":86,"title":["Effects of Plasma Glucose Concentration on Glucose Utilization and Glucose Clearance in Normal Man"],"prefix":"10.2337","volume":"30","author":[{"given":"Carlos A","family":"Verdonk","sequence":"first","affiliation":[{"name":"Endocrine Research Unit, Departments of Medicine and Physiology, Mayo Medical School and Mayo Clinic\u2008Rochester, Minnesota 55901"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A","family":"Rizza","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Departments of Medicine and Physiology, Mayo Medical School and Mayo Clinic\u2008Rochester, Minnesota 55901"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E","family":"Gerich","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Departments of Medicine and Physiology, Mayo Medical School and Mayo Clinic\u2008Rochester, Minnesota 55901"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/30\/6\/535\/351785\/30-6-535.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/30\/6\/535\/351785\/30-6-535.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:36:58Z","timestamp":1667407018000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/30\/6\/535\/6151\/Effects-of-Plasma-Glucose-Concentration-on-Glucose"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1981,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.30.6.535","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,6,1]]}}}