{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T13:53:54Z","timestamp":1720619634191},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_4","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,8,1]]},"abstract":"<jats:p>The results of islet transplantation in an animal model of spontaneous immune insulitis were studied to see whether this disease process might damage transplanted tissue. Since the insulitis occurs only in \u201cBB\u201d rats (which are not genetically uniform) syngeneic grafts could not be used, therefore allograft rejection was avoided by rendering \u201cBB\u201d rats tolerant of WF transplantation antigens by inoculating them neonatally with WF bone marrow cells. Despite the resultant tolerant state, which permitted successful engraftment of WF skin and islets transplanted to artificially diabetic \u201cBB\u201d rats, tolerant \u201cBB\u201d rats with spontaneous diabetes accepted transplanted WF islets only briefly before they were destroyed by immune insulitis.<\/jats:p>\n               <jats:p>\u201cBB\u201d rats were found to have abnormalities in immune response (delayed skin graft rejection and decreased alloreactivity in mixed lymphocyte response). However, the immune response was more normal in \u201cBB\u201d rats that were treated neonatally with WF bone marrow. Moreover, \u201cBB\u201d rats inoculated with WF bone marrow neonatally were found less likely to become diabetic than untreated \u201cBB\u201d controls. It is suggested that the chimeric state (persistence of WF bone marrow cells) may be responsible for the improved immune response and perhaps for the decreased susceptibility to diabetes.<\/jats:p>","DOI":"10.2337\/diab.31.4.s84","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"84-89","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":22,"title":["Transplantation of Islets and Bone Marrow Cells to Animals with Immune Insulitis"],"prefix":"10.2337","volume":"31","author":[{"given":"Ali","family":"Naji","sequence":"first","affiliation":[{"name":"Harrison Department of Surgical Research and Departments of Human Genetics and Pathology, University of Pennsylvania\u2008Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald","family":"Bellgrau","sequence":"additional","affiliation":[{"name":"Harrison Department of Surgical Research and Departments of Human Genetics and Pathology, University of Pennsylvania\u2008Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur","family":"Anderson","sequence":"additional","affiliation":[{"name":"Harrison Department of Surgical Research and Departments of Human Genetics and Pathology, University of Pennsylvania\u2008Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willys K","family":"Silvers","sequence":"additional","affiliation":[{"name":"Harrison Department of Surgical Research and Departments of Human Genetics and Pathology, University of Pennsylvania\u2008Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clyde F","family":"Barker","sequence":"additional","affiliation":[{"name":"Harrison Department of Surgical Research and Departments of Human Genetics and Pathology, University of Pennsylvania\u2008Philadelphia, Pennsylvania 19104"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/31\/Supplement_4\/84\/352448\/31-4-s84.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/31\/Supplement_4\/84\/352448\/31-4-s84.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:38:23Z","timestamp":1667407103000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/31\/Supplement_4\/84\/5921\/Transplantation-of-Islets-and-Bone-Marrow-Cells-to"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,8,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_4","published-print":{"date-parts":[[1982,8,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.31.4.s84","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,8,1]]}}}