{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T06:09:09Z","timestamp":1777356549027,"version":"3.51.4"},"reference-count":0,"publisher":"American Diabetes Association","issue":"9","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,9,1]]},"abstract":"<jats:p>The BioBreeding\/Worcester (BB\/W) rat is a model of spontaneous autoimmune diabetes mellitus and lymphocytic thyroiditis. Additional features supporting an immunologic pathogenesis of the BB\/W syndrome include the protective action of antilymphocyte serum, neonatal bone marrow transfusions, and neonatal thymectomy. To evaluate other manifestations of immune dysregulation, the BB\/W colony was surveyed for the presence of autoantibodies to a variety of tissue and cell constituents. Anti-smooth muscle and anti-thyroid colloid antibodies were present with great frequency in diabetic animals as well as in normoglycemic offspring of diabetic parents. Anti-parietal cell antibodies were less frequent and islet cell cytoplasmic and adrenal antibodies were not detected. These data suggest that the underlying defect in the BB\/W rat is more likely to be an abnormal immune regulatory system than antigenically altered target tissues (\u201caltered self\u201d) under attack by a normal immune surveillance system.<\/jats:p>","DOI":"10.2337\/diab.31.9.816","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"816-820","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":25,"title":["Autoantibodies in the BB\/W Rat"],"prefix":"10.2337","volume":"31","author":[{"given":"A A","family":"Like","sequence":"first","affiliation":[{"name":"University of Massachusetts Medical School\u2008Worcester, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C","family":"Appel","sequence":"additional","affiliation":[{"name":"University of Massachusetts Medical School\u2008Worcester, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A A","family":"Rossini","sequence":"additional","affiliation":[{"name":"University of Massachusetts Medical School\u2008Worcester, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/31\/9\/816\/352124\/31-9-816.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/31\/9\/816\/352124\/31-9-816.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:39:02Z","timestamp":1667407142000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/31\/9\/816\/6607\/Autoantibodies-in-the-BB-W-Rat"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,9,1]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1982,9,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.31.9.816","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,9,1]]}}}