{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T20:21:38Z","timestamp":1760646098518},"reference-count":0,"publisher":"American Diabetes Association","issue":"1","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,1,1]]},"abstract":"<jats:p>Peripheral T-lymphocytes subsets have been investigated in 36 patients with type I (insulin-dependent) diabetes of varying duration, 18 patients with type II (non-insulin-dependent) diabetes, and in 23 healthy subjects, using six different monoclonal antibodies. At the time of diagnosis of type I diabetes, there was evidence of an increase in cytotoxic T-lymphocytes, a decrease in suppressor T-lymphocytes, but a normal proportion of helper\/inducer T-lymphocytes. In six of seven newly diagnosed cases studied, there was evidence of an increased number of activated T cells. An increase in activated T-cells was also found in 5 of 10 genetically susceptible islet cell antibody positive unaffected siblings in type I diabetic probands. In type I diabetes of long standing, the total T-cell population was decreased, largely due to a marked decrease in helper\/inducer T-lymphocytes. Type II diabetic patients showed no abnormalities in T-lymphocyte subsets, making it unlikely that hyperglycemia was responsible for the changes observed. These results suggest that an imbalance of T-lymphocyte regulation is an important feature of type I diabetes and lend support for an immunologic role in its early pathogenesis.<\/jats:p>","DOI":"10.2337\/diab.32.1.91","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"91-94","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":34,"title":["Monoclonal Antibodies Defined Abnormalities of T-Lymphocytes in Type I (Insulin-dependent) Diabetes"],"prefix":"10.2337","volume":"32","author":[{"given":"P","family":"Pozzilli","sequence":"first","affiliation":[{"name":"Chair of Endocrinology (I), University of Rome Medical School\u2008Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Zuccarini","sequence":"additional","affiliation":[{"name":"Chair of Endocrinology (I), University of Rome Medical School\u2008Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Iavicoli","sequence":"additional","affiliation":[{"name":"Chair of Endocrinology (I), University of Rome Medical School\u2008Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Andreani","sequence":"additional","affiliation":[{"name":"Chair of Endocrinology (I), University of Rome Medical School\u2008Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Sensi","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Immunogenetics, St. Bartholomew's Hospital Medical College\u2008London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K M","family":"Spencer","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Immunogenetics, St. Bartholomew's Hospital Medical College\u2008London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G F","family":"Bottazzo","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Immunogenetics, St. Bartholomew's Hospital Medical College\u2008London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P C L","family":"Beverley","sequence":"additional","affiliation":[{"name":"ICRF Human Tumour Immunology Group, University College Hospital Medical School\u2008London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Kyner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Kansas, School of Medicine, Kansas City\u2008Kansas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A G","family":"Cudworth","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Immunogenetics, St. Bartholomew's Hospital Medical College\u2008London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/32\/1\/91\/352362\/32-1-91.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/32\/1\/91\/352362\/32-1-91.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:39:12Z","timestamp":1667407152000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/32\/1\/91\/5594\/Monoclonal-Antibodies-Defined-Abnormalities-of-T"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,1,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.32.1.91","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,1,1]]}}}