{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:28:52Z","timestamp":1761895732451},"reference-count":0,"publisher":"American Diabetes Association","issue":"3","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,3,1]]},"abstract":"<jats:p>Islet cell antibodies (ICA) have been measured in mature Macaca nigra. Of 30 nondiabetic monkeys, 26 (87%) were ICA-negative; of 43 monkeys with evidence of mild to severe hormonal or glycemie abnormalities, 39 (91%) were ICA-positive. Pancreatic islets were examined from biopsy and autopsy sections to assess cell deterioration and amyloid infiltration. No ICA were found in 13 of 18 (72%) monkeys with no evidence of amyloid, whereas 30 of 35 (86%) monkeys with islet amyloid and concurrent cell deterioration were ICA-positive. Association of ICA with metabolic and islet abnormalities was significant at P \u2264 0.001. ICA were specific for the islet cells in pancreatic sections; plasma preincubated with insulin, glucagon, or acetone extracts of tissues retained their ICA-positive reaction. The relationships of ICA in older monkeys to the islet lesion and to metabolic abnormalities could be relevant to similar situations in aging diabetic persons.<\/jats:p>","DOI":"10.2337\/diab.33.3.219","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"219-223","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":5,"title":["Islet Cell Cytoplasmic Antibodies in <i>Macaca nigra<\/i>"],"prefix":"10.2337","volume":"33","author":[{"suffix":"Jr","given":"Charles F","family":"Howard","sequence":"first","affiliation":[{"name":"Oregon Regional Primate Research Center\u2008505 N. W. 185th Avenue, Beaverton, Oregon 97006"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ta-Yun","family":"Fang","sequence":"additional","affiliation":[{"name":"Oregon Regional Primate Research Center\u2008505 N. W. 185th Avenue, Beaverton, Oregon 97006"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/33\/3\/219\/352788\/33-3-219.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/33\/3\/219\/352788\/33-3-219.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:41:21Z","timestamp":1667407281000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/33\/3\/219\/6247\/Islet-Cell-Cytoplasmic-Antibodies-in-Macaca-nigra"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984,3,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.33.3.219","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,3,1]]}}}