{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T10:26:37Z","timestamp":1757586397440},"reference-count":0,"publisher":"American Diabetes Association","issue":"6","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,6,1]]},"abstract":"<jats:p>Treatment of pregnant rats with cyproheptadine during the last 8 days of gestation produced alterations in the function of the endocrine pancreas in the offspring. The abnormalities exhibited by 50-day-old progeny of drug-treated dams included glucose intolerance, a twofold increase in levels of insulin in the pancreas, and an accentuated response to the insulin-lowering action of cyproheptadine in the endocrine pancreas. The alterations observed in these animals were limited to the insulin-containing cells, and no change was found in the pancreatic concentrations of glucagon and somatostatin. The results are the first to demonstrate that postnatal pancreatic B-cell function can be selectively altered by prenatal exposure to an exogenous chemical.<\/jats:p>","DOI":"10.2337\/diab.33.6.572","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"572-575","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":3,"title":["Alterations in Rat Pancreatic B-Cell Function Induced by Prenatal Exposure to Cyproheptadine"],"prefix":"10.2337","volume":"33","author":[{"given":"Samson A","family":"Chow","sequence":"first","affiliation":[{"name":"Toxicology Center, Department of Pharmacology, College of Medicine, The University of Iowa\u2008Iowa City, Iowa 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence J","family":"Fischer","sequence":"additional","affiliation":[{"name":"Toxicology Center, Department of Pharmacology, College of Medicine, The University of Iowa\u2008Iowa City, Iowa 52242"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/33\/6\/572\/336493\/33-6-572.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/33\/6\/572\/336493\/33-6-572.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:41:53Z","timestamp":1667407313000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/33\/6\/572\/6076\/Alterations-in-Rat-Pancreatic-B-Cell-Function"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1984,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.33.6.572","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,6,1]]}}}