{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:28:54Z","timestamp":1761895734977},"reference-count":0,"publisher":"American Diabetes Association","issue":"3","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,3,1]]},"abstract":"<jats:p>An ascochlorin derivative, AS-6, is a new hypoglycemic agent orally active in both obese hyperinsulineroic and insulin-deficient diabetic animal models. AS-6, when given as a 0.025\u20130.2% admixture in the diet, dose-dependently ameliorated polydipsia, polyuria, and glycosuria in the genetically obese diabetic mouse, C57BL\/KsJ db\/db, while neither insulin nor tolbutamide showed any beneficial effects. The amelioration by AS-6 was associated with a marked decrease in serum glucose and triglyceride. The effects persisted at least 10 wk, accompanied by a steady decrease in drinking water consumption. The chronic treatment prevented pancreatic islet degeneration, e.g., degranulation of the \u03b2-cells, basophilic appearance of the exocrine border around the islets, and small round cell infiltration. The isolated islets from AS-6-treated mice released much more insulin in response to glucose than those from untreated controls. A significant correlation between serum immunoreactive insulin and glucose\/triglyceride from both treated and untreated mice suggests that AS-6 restores sensitivity and responsiveness to insulin to the mice.<\/jats:p>\n               <jats:p>In fact, the combined treatment with insulin synergistically decreased serum glucose by 50% below AS-6 treatment alone. Furthermore, the epididymal fat pad slices from AS-6-treated db\/db mice increased CO2 generation and lipogenesis over the untreated controls, and the glucose metabolic rate (CO2 generation plus lipogenesis from U-[14C]-glucose) in the slices and the serum glucose level inversely correlated at r = 0.8799. These facts indicate that AS-6 reduces insulin resistance in db\/db mice.<\/jats:p>","DOI":"10.2337\/diab.34.3.267","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"267-274","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":41,"title":["An Ascochlorin Derivative, AS-6, Reduces Insulin Resistance in the Genetically Obese Diabetic Mouse, <i>db<\/i>\/<i>db<\/i>"],"prefix":"10.2337","volume":"34","author":[{"given":"Tomoyoshi","family":"Hosokawa","sequence":"first","affiliation":[{"name":"Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo\u2008Yayoi 1-1, Bunkyo-ku, Tokyo 113, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunio","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo\u2008Yayoi 1-1, Bunkyo-ku, Tokyo 113, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gakuzo","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Agricultural Chemistry, Faculty of Agriculture, University of Tokyo\u2008Yayoi 1-1, Bunkyo-ku, Tokyo 113, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/34\/3\/267\/353679\/34-3-267.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/34\/3\/267\/353679\/34-3-267.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:43:29Z","timestamp":1667407409000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/34\/3\/267\/7459\/An-Ascochlorin-Derivative-AS-6-Reduces-Insulin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,3,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.34.3.267","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,3,1]]}}}