{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T05:56:00Z","timestamp":1761976560169,"version":"build-2065373602"},"reference-count":0,"publisher":"American Diabetes Association","issue":"1","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,1,1]]},"abstract":"<jats:p>Type A insulin resistance, associated with acanthosis nigricans and menstrual irregularity, has been ascribed to a decreased concentration of insulin receptors. We now report four affected females from one family, a mother and three daughters (including identical twins) who appear to have the type A syndrome. Two of the kindred had no apparent ovarian dysfunction, while the other two had hyperprolactinemia without other findings of polycystic ovary disease, suggesting a genetic disease with variable penetrance. All had normal erythrocyte and monocyte insulin binding. Insulin dose-response studies to assess glucose metabolism and insulinsensitivity were performed in the affected twins. The dose response to insulin was shifted to the right with a decrease in maximal response. These results are consistent with a postbinding defect in insulin action in these patients.<\/jats:p>","DOI":"10.2337\/diab.35.1.33","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"33-37","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":13,"title":["Familial Insulin Resistance and Acanthosis Nigricans: Presence of a Postbinding Defect"],"prefix":"10.2337","volume":"35","author":[{"given":"W Frederick","family":"Schwenk","sequence":"first","affiliation":[{"name":"Endocrine Research Unit, Departments of Pediatrics and Medicine, Mayo Clinic and Foundation\u2008Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A","family":"Rizza","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Departments of Pediatrics and Medicine, Mayo Clinic and Foundation\u2008Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence J","family":"Mandarino","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Departments of Pediatrics and Medicine, Mayo Clinic and Foundation\u2008Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E","family":"Gerich","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Departments of Pediatrics and Medicine, Mayo Clinic and Foundation\u2008Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvin B","family":"Hayles","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Departments of Pediatrics and Medicine, Mayo Clinic and Foundation\u2008Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morey W","family":"Haymond","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Departments of Pediatrics and Medicine, Mayo Clinic and Foundation\u2008Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/35\/1\/33\/354265\/35-1-33.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/35\/1\/33\/354265\/35-1-33.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:44:36Z","timestamp":1667407476000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/35\/1\/33\/7831\/Familial-Insulin-Resistance-and-Acanthosis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,1,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.35.1.33","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"type":"print","value":"0012-1797"},{"type":"electronic","value":"1939-327X"}],"subject":[],"published":{"date-parts":[[1986,1,1]]}}}