{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:15:36Z","timestamp":1791065736137,"version":"4.1.0"},"reference-count":0,"publisher":"American Diabetes Association","issue":"4","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,4,1]]},"abstract":"<jats:p>We analyzed the surface phenotypes of infiltrated cells in pancreases of nonobese diabetic (NOD) mice with monoclonal antibodies to mouse lymphocytes. Most of the infiltrated cells were Thy1+ and Ly1+ T-lymphocytes, and most of them were L3T4+ helper T-lymphocyte subsets. To elucidate the role of L3T4+ T-lymphocytes in the development of insulitis and diabetes in NOD mice, we treated the animals with injections of monoclonal anti-L3T4 antibody. Administration of this antibody prevented the insulitis and diabetes in NOD mice. These results lead to conclusions that the L3T4+ helper T-lymphocytes may play an essential role in the pathogenesis of type I diabetes and that the manipulation of the OKT4+ (Leu3+) T-lymphocyte subset, the human homology of L3T4, with monoclonal antibodies may provide effective therapy for human type I diabetes.<\/jats:p>","DOI":"10.2337\/diab.36.4.539","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"539-541","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":82,"title":["Preventive Effect of Monoclonal Anti-L3T4 Antibody on Development of Diabetes in NOD Mice"],"prefix":"10.2337","volume":"36","author":[{"given":"Takao","family":"Koike","sequence":"first","affiliation":[{"name":"Second Department of Internal Medicine, the Laboratory Animal Center, Chiba University School of Medicine\u2008Chiba, and the Department of Pathology, Tokyo Metropolitan Institute of Gerontology\u2008Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohjiro","family":"Itoh","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, the Laboratory Animal Center, Chiba University School of Medicine\u2008Chiba, and the Department of Pathology, Tokyo Metropolitan Institute of Gerontology\u2008Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuko","family":"Ishii","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, the Laboratory Animal Center, Chiba University School of Medicine\u2008Chiba, and the Department of Pathology, Tokyo Metropolitan Institute of Gerontology\u2008Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Ito","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, the Laboratory Animal Center, Chiba University School of Medicine\u2008Chiba, and the Department of Pathology, Tokyo Metropolitan Institute of Gerontology\u2008Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Takabayashi","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, the Laboratory Animal Center, Chiba University School of Medicine\u2008Chiba, and the Department of Pathology, Tokyo Metropolitan Institute of Gerontology\u2008Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, the Laboratory Animal Center, Chiba University School of Medicine\u2008Chiba, and the Department of Pathology, Tokyo Metropolitan Institute of Gerontology\u2008Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisao","family":"Tomioka","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, the Laboratory Animal Center, Chiba University School of Medicine\u2008Chiba, and the Department of Pathology, Tokyo Metropolitan Institute of Gerontology\u2008Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, the Laboratory Animal Center, Chiba University School of Medicine\u2008Chiba, and the Department of Pathology, Tokyo Metropolitan Institute of Gerontology\u2008Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/36\/4\/539\/512333\/36-4-539.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/36\/4\/539\/512333\/36-4-539.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:07:09Z","timestamp":1667405229000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/36\/4\/539\/6739\/Preventive-Effect-of-Monoclonal-Anti-L3T4-Antibody"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,4,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.36.4.539","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,4,1]]}}}