{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:27:51Z","timestamp":1791779271070,"version":"4.3.4"},"reference-count":0,"publisher":"American Diabetes Association","issue":"10","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,10,1]]},"abstract":"<jats:p>Diabetogenic strains of Coxsackievirus B4 (CB4) produce a diabetes syndrome in susceptible mice that resembles insulin-dependent diabetes mellitus. To assess the possible role of autoimmunity, the expression of a 64,000-Mr islet antigen in SJL\/J and CD1 mice infected with a diabetogenic strain of CB4 was monitored in early and late infection. Additionally, virus-induced abnormalities in glucose metabolism were correlated with several changes in purified islets to assess \u03b2-cell physiology. Over 80% of the mice exhibited subnormal blood glucose at 72 h postinfection (p.i.) and were hyperglycemie at 6 and 8 wk p.i. Islet yield in infected mice decreased by 29\u201347% at 72 h and 6 wk p.i. compared to noninfected mice. Insulin release stimulated by 16.7 mM glucose increased greater than twofold at 72 h p.i. but declined at 6 wk well below the level of noninfected mice. Likewise, residual islet insulin content after release also increased at 72 h and then declined. Total protein synthesis in the islets decreased by 30% at 72 h and by 60% at 6 wk p.i. Although the synthesis of five proteins of heterogeneous molecular weights, including tubulin, was severely depressed in the infected islets at 72 h p.i. compared with control islets or islets at 6 wk p.i., synthesis of the 64,000-Mr component and another protein of 36,000 Mr increased by two- to threefold. It is possible that CB4 infection may initiate or enhance an autoimmune reaction by increased expression of the 64,000-Mr antigen.<\/jats:p>","DOI":"10.2337\/diab.37.10.1419","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"1419-1425","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":17,"title":["Effect of Coxsackievirus B4 Infection in Mice on Expression of 64,000-<i>M<\/i>r Autoantigen and Glucose Sensitivity of Islets Before Development of Hyperglycemia"],"prefix":"10.2337","volume":"37","author":[{"given":"Ivan","family":"Gerling","sequence":"first","affiliation":[{"name":"Wadsworth Center for Laboratories and Research, New York State Department of Health\u2008Albany, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Nejman","sequence":"additional","affiliation":[{"name":"Wadsworth Center for Laboratories and Research, New York State Department of Health\u2008Albany, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nando K","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Wadsworth Center for Laboratories and Research, New York State Department of Health\u2008Albany, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/37\/10\/1419\/355743\/37-10-1419.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/37\/10\/1419\/355743\/37-10-1419.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:08:13Z","timestamp":1667405293000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/37\/10\/1419\/8451\/Effect-of-Coxsackievirus-B4-Infection-in-Mice-on"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1988,10,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.37.10.1419","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,10,1]]}}}