{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T16:58:29Z","timestamp":1777481909037,"version":"3.51.4"},"reference-count":0,"publisher":"American Diabetes Association","issue":"6","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,6,1]]},"abstract":"<jats:p>Central and lateral hypothalamic concentrations of 10 regulatory peptides were measured by radioimmunoassay in streptozocin-induced diabetic (STZ-D) and matched control rats between 1 day and 14 wk after diabetes induction. After 2 wk, both central and lateral hypothalamic neuropeptide Y (NPY) concentrations in STZ-D rats were consistently higher than those found in control rats, with significant 30\u201350% increases at 4 wk in the central hypothalamus, and at 6 and 14 wk in both central and lateral hypothalamus. Immunocytochemical studies in 4- and 6-wk STZ-D animals showed the appearance of intensely NPY-positive swollen cell bodies in the supraoptic nucleus and a subjective increase in NPY staining of medial hypothalamic nerve fibers. Central hypothalamic concentrations of three other peptides were significantly greater in STZ-D animals than those in control animals at single points (neurotensin, 1 day; calcitonin gene-related peptide, 2 wk; neurokinin, 4 wk). Hypothalamic concentrations of the other six peptides examined (bombesin, galanin, neuromedin B, substance P, somatostatin, and vasoactive intestinal peptide) did not differ significantly between STZ-D and control groups at any time. However, galanin immunostaining in the supraoptic and magnocellular paraventricular nuclei was strikingly concentrated in a reduced number of distended cell bodies. Hypothalamic peptide changes in STZ-D could be related to metabolic disturbance, changes in energy and water balance, altered pituitary function, or other factors. Persistently elevated concentrations of NPY, a very potent central stimulant of eating and drinking, may mediate the hyperphagia and polydipsia characteristic of STZ-D.<\/jats:p>","DOI":"10.2337\/diab.37.6.763","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"763-772","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":53,"title":["Increased Hypothalamic Neuropeptide Y Concentrations in Diabetic Rat"],"prefix":"10.2337","volume":"37","author":[{"given":"Gareth","family":"Williams","sequence":"first","affiliation":[{"name":"Francis Fraser Laboratories, Department of Medicine and Department of Histochemistry, Royal Postgraduate Medical School\u2008London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer H","family":"Steel","sequence":"additional","affiliation":[{"name":"Francis Fraser Laboratories, Department of Medicine and Department of Histochemistry, Royal Postgraduate Medical School\u2008London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Francis Fraser Laboratories, Department of Medicine and Department of Histochemistry, Royal Postgraduate Medical School\u2008London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad A","family":"Ghatei","sequence":"additional","affiliation":[{"name":"Francis Fraser Laboratories, Department of Medicine and Department of Histochemistry, Royal Postgraduate Medical School\u2008London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying C","family":"Lee","sequence":"additional","affiliation":[{"name":"Francis Fraser Laboratories, Department of Medicine and Department of Histochemistry, Royal Postgraduate Medical School\u2008London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaswinder S","family":"Gill","sequence":"additional","affiliation":[{"name":"Francis Fraser Laboratories, Department of Medicine and Department of Histochemistry, Royal Postgraduate Medical School\u2008London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacky M","family":"Burrin","sequence":"additional","affiliation":[{"name":"Francis Fraser Laboratories, Department of Medicine and Department of Histochemistry, Royal Postgraduate Medical School\u2008London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia M","family":"Polak","sequence":"additional","affiliation":[{"name":"Francis Fraser Laboratories, Department of Medicine and Department of Histochemistry, Royal Postgraduate Medical School\u2008London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen R","family":"Bloom","sequence":"additional","affiliation":[{"name":"Francis Fraser Laboratories, Department of Medicine and Department of Histochemistry, Royal Postgraduate Medical School\u2008London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/37\/6\/763\/355851\/37-6-763.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/37\/6\/763\/355851\/37-6-763.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:09:22Z","timestamp":1667405362000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/37\/6\/763\/7213\/Increased-Hypothalamic-Neuropeptide-Y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1988,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.37.6.763","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,6,1]]}}}