{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T10:58:03Z","timestamp":1698577083957},"reference-count":0,"publisher":"American Diabetes Association","issue":"Supplement_1","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,1,1]]},"abstract":"<jats:p>Between January 1985 and September 1987, we performed a prospective comparative study between segmental-pancreas transplantation with duct obstruction by neoprene (n = 17) and pancreaticoduodenal transplantation with enteric diversion to a Roux-en-Y intestinal loop (n = 14). All recipients had insulin-dependent diabetes. The immunosuppressive protocol consisted of low doses of the steroids cyclosporin A and azathioprine. Mean follow-up was 16.5 mo for the enteric-diversion group and 13.5 mo for duct-obstructed groups. Two-year patient and pancreas- and kidney-graft actuarial survival rates were 92.9, 75.5, and 74.2%, respectively, in the former group and 92.3, 58.4, and 63.7%, respectively, in the latter group (NS). Five whole-organ grafts were lost (3 vascular thromboses, 1 pancreatitis, 1 rejection), and four segmental grafts were lost (2 vascular thromboses, 1 bleeding, 1 patient's death with functional graft). More surgical complications occurred in the recipients of whole-organ grafts and were often related to the intestinal anastomosis. A satisfactory blood glucose control was observed at 3 mo and 1 yr in both groups. Provocative tests showed higher and prompter insulin secretion in patients with wholeorgan grafts. In patients with segmental grafts, the response was lower and delayed with a general tendency to impaired glucose tolerance. A marked hyperinsulinemia after meals was observed in whole-organ graft recipients. Slight nocturnal hyperinsulinemia was observed in both groups. At 1 yr, glycosylated hemoglobin was normal in both groups. The absence of a significant difference between the two groups, in terms of survival and graft function, and the lower surgical complication rate seen with segmental grafts have made us return to neo p re ne-injected segmental grafts.<\/jats:p>","DOI":"10.2337\/diab.38.1.s16","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"16-17","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":11,"title":["Segmental Duct-Obstructed Pancreas Grafts Versus Pancreaticoduodenal Grafts With Enteric Diversion"],"prefix":"10.2337","volume":"38","author":[{"given":"Xavier","family":"Martin","sequence":"first","affiliation":[{"name":"Service d'Urologie et de chirurgie de la transplantation, E. Herriot Hospital\u2008Lyon, France; Medical Clinic VII, Scientific Institute H.S. Raffaele\u2008Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Michel","family":"Dubernard","sequence":"additional","affiliation":[{"name":"Service d'Urologie et de chirurgie de la transplantation, E. Herriot Hospital\u2008Lyon, France; Medical Clinic VII, Scientific Institute H.S. Raffaele\u2008Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Sanseverino","sequence":"additional","affiliation":[{"name":"Service d'Urologie et de chirurgie de la transplantation, E. Herriot Hospital\u2008Lyon, France; Medical Clinic VII, Scientific Institute H.S. Raffaele\u2008Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Melandri","sequence":"additional","affiliation":[{"name":"Service d'Urologie et de chirurgie de la transplantation, E. Herriot Hospital\u2008Lyon, France; Medical Clinic VII, Scientific Institute H.S. Raffaele\u2008Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Louis","family":"Faure","sequence":"additional","affiliation":[{"name":"Service d'Urologie et de chirurgie de la transplantation, E. Herriot Hospital\u2008Lyon, France; Medical Clinic VII, Scientific Institute H.S. Raffaele\u2008Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Camozzi","sequence":"additional","affiliation":[{"name":"Service d'Urologie et de chirurgie de la transplantation, E. Herriot Hospital\u2008Lyon, France; Medical Clinic VII, Scientific Institute H.S. Raffaele\u2008Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"LeFrancois","sequence":"additional","affiliation":[{"name":"Service d'Urologie et de chirurgie de la transplantation, E. Herriot Hospital\u2008Lyon, France; Medical Clinic VII, Scientific Institute H.S. Raffaele\u2008Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ennio","family":"Rocca","sequence":"additional","affiliation":[{"name":"Service d'Urologie et de chirurgie de la transplantation, E. Herriot Hospital\u2008Lyon, France; Medical Clinic VII, Scientific Institute H.S. Raffaele\u2008Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alber","family":"Gelet","sequence":"additional","affiliation":[{"name":"Service d'Urologie et de chirurgie de la transplantation, E. Herriot Hospital\u2008Lyon, France; Medical Clinic VII, Scientific Institute H.S. Raffaele\u2008Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/38\/Supplement_1\/16\/514759\/38-1-s16.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/38\/Supplement_1\/16\/514759\/38-1-s16.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:10:33Z","timestamp":1667405433000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/38\/Supplement_1\/16\/14990\/Segmental-Duct-Obstructed-Pancreas-Grafts-Versus"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1,1]]},"references-count":0,"journal-issue":{"issue":"Supplement_1","published-print":{"date-parts":[[1989,1,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.38.1.s16","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,1,1]]}}}