{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:49:56Z","timestamp":1760100596372},"reference-count":0,"publisher":"American Diabetes Association","issue":"10","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,10,1]]},"abstract":"<jats:p>Previous studies have shown that adenosine, by activation of purinergic A2-receptors, stimulates glucagon secretion and increases vascular flow rate in isolated perfused pancreases from nondiabetic rats. Because \u03b1-cell function and blood flow control are known to be disturbed in diabetes, we investigated whether adenosine was still effective in streptozocininduced diabetic (STZ-D) rats. Our experiments were performed on isolated perfused rat pancreases. Whereas, in normal rats, adenosine (1.65 \u03bcM) induced a 200% increase in glucagon output and a 25% rise in the pancreatic vascular flow rate, in rats diabetic for 5\u20136 wk, this nucleoside was ineffective on glucagon secretion, and its vasodilatory effect was strongly reduced. Long-term in vivo insulin treatment that reversed high glycemia levels was able to restore in large part both adenosine effects. In contrast, a shortterm in vitro pretreatment with insulin was unable to restore the nucleoside effects. We conclude that STZ-D suppresses the stimulatory effect of adenosine on \u03b1-cells and strongly reduces its vasodilator properties; these abnormalities may be corrected in large part by long-term insulin treatment with normalization of glycemia.<\/jats:p>","DOI":"10.2337\/diab.38.10.1291","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"1291-1295","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":8,"title":["Diabetes and Impaired Response of Glucagon Cells and Vascular Bed to Adenosine in Rat Pancreas"],"prefix":"10.2337","volume":"38","author":[{"given":"Ren\u00e9","family":"Gross","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Pharmacology Laboratory, Unit\u00e9 de Recherche Associe\u00e9 599 du Centre National de la Recherche Scientifique\u2008Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Hillaire-Buys","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pharmacology Laboratory, Unit\u00e9 de Recherche Associe\u00e9 599 du Centre National de la Recherche Scientifique\u2008Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyslaine","family":"Bertrand","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pharmacology Laboratory, Unit\u00e9 de Recherche Associe\u00e9 599 du Centre National de la Recherche Scientifique\u2008Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00e9rard","family":"Ribes","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pharmacology Laboratory, Unit\u00e9 de Recherche Associe\u00e9 599 du Centre National de la Recherche Scientifique\u2008Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Madeleine","family":"Loubatieres-Mariani","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pharmacology Laboratory, Unit\u00e9 de Recherche Associe\u00e9 599 du Centre National de la Recherche Scientifique\u2008Montpellier, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/38\/10\/1291\/356254\/38-10-1291.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/38\/10\/1291\/356254\/38-10-1291.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:11:19Z","timestamp":1667405479000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/38\/10\/1291\/8533\/Diabetes-and-Impaired-Response-of-Glucagon-Cells"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1989,10,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.38.10.1291","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,10,1]]}}}