{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:34:50Z","timestamp":1782549290279,"version":"3.54.5"},"reference-count":0,"publisher":"American Diabetes Association","issue":"3","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,3,1]]},"abstract":"<jats:p>Glucagonlike peptide I (7\u201337) [GLP-I-(7\u201337)], encoded with glucagon and glucagonlike peptide II and intervening peptide II in the rat and human glucagon gene, is processed from proglucagon in both pancreas and intestine and is a potent stimulator of insulin secretion. Unequivocal insulin release from the isolated perfused rat pancreas is elicited by a 10\u221211 M concentration of this peptide, and a weak response is found at 10\u221212 M. We found that GLP-I-(7\u201337) is \u223c100 times more potent than glucagon in the stimulation of insulin secretion. Insulin release in response to GLP-I-(7\u201337) is highly dependent on the ambient glucose concentration; no response is detectable at a glucose concentration of 2.8 mM, and at 6.6 and 16.7 mM, insulin release is augmented by 4.7 and 22.8 ng\/ml, respectively. The pattern of insulin secretion stimulated by GLP-I-(7\u201337) is biphasic, with an initial spike followed by a plateau of sustained release. The effects on insulin release of GLP-I-(7\u201336) amide, a GLP-I analogue, and GLP-I-(7\u201337) at concentrations of 10\u221211 M were indistinguishable. We also found that GLP-I-(7\u201337) at 10\u22129 M does not influence glucagon secretion and that glucagonlike peptide II and the intervening peptide II, two other peptides encoded by the glucagon gene, have no detectable effects on insulin secretion.<\/jats:p>","DOI":"10.2337\/diab.38.3.338","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"338-342","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":158,"title":["Glucagonlike Peptide I (7\u201337) Actions on Endocrine Pancreas"],"prefix":"10.2337","volume":"38","author":[{"given":"Gordon C","family":"Weir","sequence":"first","affiliation":[{"name":"Joslin Diabetes Center and New England Deaconess Hospital, Harvard and the Laboratory of Molecular Endocrinology, Massachusetts General Hospital and Howard Hughes Medical Institute, Harvard Medical School\u2008Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Mojsov","sequence":"additional","affiliation":[{"name":"Joslin Diabetes Center and New England Deaconess Hospital, Harvard and the Laboratory of Molecular Endocrinology, Massachusetts General Hospital and Howard Hughes Medical Institute, Harvard Medical School\u2008Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant K","family":"Hendrick","sequence":"additional","affiliation":[{"name":"Joslin Diabetes Center and New England Deaconess Hospital, Harvard and the Laboratory of Molecular Endocrinology, Massachusetts General Hospital and Howard Hughes Medical Institute, Harvard Medical School\u2008Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel F","family":"Habener","sequence":"additional","affiliation":[{"name":"Joslin Diabetes Center and New England Deaconess Hospital, Harvard and the Laboratory of Molecular Endocrinology, Massachusetts General Hospital and Howard Hughes Medical Institute, Harvard Medical School\u2008Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/38\/3\/338\/356739\/38-3-338.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/38\/3\/338\/356739\/38-3-338.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:12:06Z","timestamp":1667405526000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/38\/3\/338\/8563\/Glucagonlike-Peptide-I-7-37-Actions-on-Endocrine"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,3,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.38.3.338","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,3,1]]}}}