{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:29:18Z","timestamp":1761895758550},"reference-count":0,"publisher":"American Diabetes Association","issue":"4","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,4,1]]},"abstract":"<jats:p>This study investigated the effects of cyclosporin (Cs) on insulin secretion and synthesis from the endocrine pancreas. With in vitro perfused pancreases from control and Cs-treated rats (1, 5,10, or 25 mg \u00b7 kg\u22121 \u00b7 day\u22121 for 2 wk), a dose-response relationship between Cs dose and inhibition of insulin secretion was demonstrated. Examination of the dynamic secretory response to a glucose stimulus (200 mg\/dl) over a 3-h perfusion revealed an inhibition of all three secretory phases. Similarly, the ability of the pancreases to synthesize insulin decreased as a function of Cs dose. Reversibility of Cs toxicity on the pancreas was established by 2 wk after cessation of treatment. To evaluate the effect of Cs treatment in vivo, intravenous glucose tolerance tests were performed. Rats treated with 25 mg \u00b7 kg\u22121 \u00b7 day\u22121 Cs for 2 wk had significantly lower k values (slope of log glucose concentration over time) than controls. At 10 mg \u00b7 kg\u22121 \u00b7 day1, although curves that appeared abnormal were observed, k values were not significantly different from those of controls. In summary, this study demonstrates the profound inhibitory effect of Cs on the endocrine pancreas.<\/jats:p>","DOI":"10.2337\/diab.38.4.465","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"465-470","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":14,"title":["Synthesis-Secretion Coupling of Insulin: Effect of Cyclosporin"],"prefix":"10.2337","volume":"38","author":[{"given":"Susan L","family":"Gillison","sequence":"first","affiliation":[{"name":"Departments of Physiological Sciences and Surgery, Schools of Veterinary Medicine and Medicine, University of California\u2008Davis, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen T","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Departments of Physiological Sciences and Surgery, Schools of Veterinary Medicine and Medicine, University of California\u2008Davis, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald L","family":"Curry","sequence":"additional","affiliation":[{"name":"Departments of Physiological Sciences and Surgery, Schools of Veterinary Medicine and Medicine, University of California\u2008Davis, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/38\/4\/465\/356695\/38-4-465.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/38\/4\/465\/356695\/38-4-465.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:12:17Z","timestamp":1667405537000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/38\/4\/465\/7205\/Synthesis-Secretion-Coupling-of-Insulin-Effect-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,4,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.38.4.465","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,4,1]]}}}