{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:02:10Z","timestamp":1791075730034,"version":"4.1.0"},"reference-count":0,"publisher":"American Diabetes Association","issue":"7","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,7,1]]},"abstract":"<jats:p>We examined the effect of glucagonlike peptides (GLPs), which are cleaved from preproglucagon in the enteroglucagon cells, on rat endocrine pancreas with the isolated perfused system. GLP-I-(7\u201336)-amide, a truncated form of full-sequence GLP-I-(1\u201337), showed a potent inhibitory effect on glucagon secretion. This inhibitory effect of GLP-I-(7\u201336)-amide was demonstrated at concentrations of 0.25, 2.5, and 25 nM in 11.2 and 2.8 mM glucose. In contrast, insulin release was significantly stimulated by GLP-I-(7\u201336)-amide at its concentration from 0.025 to 25 nM in a high glucose concentration, whereas in a low glucose concentration, the stimulation was seen only at the highest concentration (25 nM). Neither GLP-I-(1\u201337) nor GLP-II showed any effect on glucagon and insulin release. Although several gastrointestinal hormones have been nominated as incretins, none of them may suppress the glucagon secretion. A truncated form of GLP-I, GLP-I-(7\u201336)-amide thus seems to be a unique incretin that exerts glucagonostatic action.<\/jats:p>","DOI":"10.2337\/diab.38.7.902","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"902-905","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":151,"title":["Glucagonostatic and Insulinotropic Action of Glucagonlike Peptide I-(7\u201336)-Amide"],"prefix":"10.2337","volume":"38","author":[{"given":"Ryoya","family":"Komatsu","sequence":"first","affiliation":[{"name":"The Second Department of Internal Medicine, Osaka University Medical School, and the Division of Clinical Laboratory, National Cardiovascular Center Hospital\u2008Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine, Osaka University Medical School, and the Division of Clinical Laboratory, National Cardiovascular Center Hospital\u2008Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuyoshi","family":"Namba","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine, Osaka University Medical School, and the Division of Clinical Laboratory, National Cardiovascular Center Hospital\u2008Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuaki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine, Osaka University Medical School, and the Division of Clinical Laboratory, National Cardiovascular Center Hospital\u2008Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiko","family":"Itoh","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine, Osaka University Medical School, and the Division of Clinical Laboratory, National Cardiovascular Center Hospital\u2008Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Kono","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine, Osaka University Medical School, and the Division of Clinical Laboratory, National Cardiovascular Center Hospital\u2008Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichiro","family":"Tarui","sequence":"additional","affiliation":[{"name":"The Second Department of Internal Medicine, Osaka University Medical School, and the Division of Clinical Laboratory, National Cardiovascular Center Hospital\u2008Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/38\/7\/902\/356785\/38-7-902.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/38\/7\/902\/356785\/38-7-902.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:12:50Z","timestamp":1667405570000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/38\/7\/902\/8937\/Glucagonostatic-and-Insulinotropic-Action-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,7,1]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1989,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.38.7.902","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,7,1]]}}}