{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:54:39Z","timestamp":1757541279455},"reference-count":0,"publisher":"American Diabetes Association","issue":"7","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1989,7,1]]},"abstract":"<jats:p>The etiology of autonomic neuropathy in insulin-dependent diabetes mellitus (IDDM) is unknown. Previous studies have noted the presence of anti-adrenal medullary antibodies in IDDM. Recently, we have also demonstrated the presence of anti-sympathetic ganglia antibodies in IDDM. We initiated a study to evaluate whether subjects with complement-fixing anti-adrenal medullary (CF-ADM) and anti-sympathetic ganglia (CF-SG) antibodies have a decreased catecholamine response to change in posture. Seven IDDM subjects aged 19\u201341 yr with duration of disease 5\u201321 yr at the time of the posture study were evaluated. Serums collected longitudinally were evaluated for the presence of CF-ADM and CF-SG antibodies. Three IDDM subjects were CF-ADM\u2212 and CF-SG\u2212 at all testing intervals (Ab\u2212 group). Four IDDM subjects were CF-ADM+ and\/or CF-SG+ on at least one testing date (Ab+ group). Baseline mean norepinephrine and epinephrine levels were not significantly different in Ab+ and Ab\u2212 subjects. Norepinephrine levels 5 min after standing were mean \u00b1 SD 227 \u00b116 and 419 \u00b1 48 pg\/ml for Ab+ and Ab\u2212 subjects, respectively (P &amp;lt; .03). The means of the 5-min minus basal norepinephrine levels were 88 \u00b1 42 (Ab+) and 207 \u00b1 26 (Ab\u2212) pg\/ml (P &amp;lt; .03). Mean epinephrine levels after 5 min of standing were 35 \u00b116 (Ab+) and 101 \u00b1 44 (Ab\u2212) pg\/ml (P &amp;lt; .03). The means of the 5-min minus basal epinephrine levels were 1 \u00b1 5 (Ab+) and 43 \u00b1 38 (Ab) pg\/ml (P &amp;lt; .03). Mean change in systolic blood pressure on standing was not different in the two groups. This suggests that CF-ADM and CF-SG are associated with a decreased catecholamine response to change in posture.<\/jats:p>","DOI":"10.2337\/diab.38.7.938","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:16:02Z","timestamp":1379610962000},"page":"938-941","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":9,"title":["Anti-Sympathetic Nervous System Autoantibodies: Diminished Catecholamines With Orthostasis"],"prefix":"10.2337","volume":"38","author":[{"given":"Florence M","family":"Brown","sequence":"first","affiliation":[{"name":"Immunology Section, Joslin Diabetes Center; the Division of Diabetes and Metabolism, Brigham and Women's Hospital; Harvard Medical School; Children's Hospital Medical Center, Neurology Section, New England Deaconess Hospital\u2008Boston\u2008New England Diabetes and Endocrine Center\u2008Chestnut Hill, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart J","family":"Brink","sequence":"additional","affiliation":[{"name":"Immunology Section, Joslin Diabetes Center; the Division of Diabetes and Metabolism, Brigham and Women's Hospital; Harvard Medical School; Children's Hospital Medical Center, Neurology Section, New England Deaconess Hospital\u2008Boston\u2008New England Diabetes and Endocrine Center\u2008Chestnut Hill, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"Freeman","sequence":"additional","affiliation":[{"name":"Immunology Section, Joslin Diabetes Center; the Division of Diabetes and Metabolism, Brigham and Women's Hospital; Harvard Medical School; Children's Hospital Medical Center, Neurology Section, New England Deaconess Hospital\u2008Boston\u2008New England Diabetes and Endocrine Center\u2008Chestnut Hill, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven L","family":"Rabinowe","sequence":"additional","affiliation":[{"name":"Immunology Section, Joslin Diabetes Center; the Division of Diabetes and Metabolism, Brigham and Women's Hospital; Harvard Medical School; Children's Hospital Medical Center, Neurology Section, New England Deaconess Hospital\u2008Boston\u2008New England Diabetes and Endocrine Center\u2008Chestnut Hill, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/38\/7\/938\/356712\/38-7-938.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/38\/7\/938\/356712\/38-7-938.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:12:53Z","timestamp":1667405573000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/38\/7\/938\/8961\/Anti-Sympathetic-Nervous-System-Autoantibodies"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,7,1]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1989,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.38.7.938","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,7,1]]}}}