{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:56:01Z","timestamp":1770836161215,"version":"3.50.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"10","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,10,1]]},"abstract":"<jats:p>Human CD5+ B lymphocytes produce autoantibodies that bind to self- and exogenous antigens. Extremely high percentages of CD5+ B lymphocytes are present in the fetal and newborn periods, whereas they constitute only a minority of B lymphocytes in healthy adults. Increased percentages of circulating CD5+ lymphocytes have previously been demonstrated in several autoimmune diseases, including rheumatoid arthritis, progressive systemic sclerosis, Graves' disease, and Sj\u00f6gren's syndrome. We measured the percentages of B lymphocytes that expressed the CD5 determinant in 93 control subjects (age range 1 day to 59 yr, mean \u00b1 SD 22.6 \u00b1 17.7 yr), 17 subjects with newly diagnosed insulin-dependent diabetes mellitus (IDDM; range 5'29 yr, mean \u00b1 SD 13 \u00b1 5.9 yr), 31 high-risk islet cell antibody (ICA)-positive nondiabetic subjects (range 4\u201345 yr, mean \u00b1 SD 19.8 \u00b1 14.1 yr), and 13 subjects with IDDM of &amp;gt;5 yr duration (range 10\u201343 yr, mean \u00b1 SD 24.2 \u00b1 9.9 yr). We report that CD5+ B-lymphocyte percentages are strikingly age dependent in healthy control subjects, declining progressively from the newborn period to the middle-age years (r = \u22120.75, P = 0.0001). In ICA+ nondiabetic and recent-onset IDDM subjects &amp;lt;29 yr of age, the percentage of circulating CD5+ B lymphocytes fell within the 95% confidence intervals established for control subjects. However, the age-dependent rate of decline in the percentage of CD5+ B lymphocytes within the control range was slower in ICA+ and newly diagnosed IDDM subjects than in control subjects.<\/jats:p>","DOI":"10.2337\/diab.40.10.1314","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:22:06Z","timestamp":1379611326000},"page":"1314-1318","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":7,"title":["CD5+ B Lymphocytes in High-Risk Islet Cell Antibody\u2013Positive and Newly Diagnosed IDDM Subjects"],"prefix":"10.2337","volume":"40","author":[{"given":"Desmond A","family":"Schatz","sequence":"first","affiliation":[{"name":"Departments of Pediatrics and Pathology and Laboratory Medicine, University of Florida College of Medicine\u2008Gainesville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois","family":"Lang","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Pathology and Laboratory Medicine, University of Florida College of Medicine\u2008Gainesville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan B","family":"Cantor","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Pathology and Laboratory Medicine, University of Florida College of Medicine\u2008Gainesville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J","family":"Riley","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Pathology and Laboratory Medicine, University of Florida College of Medicine\u2008Gainesville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noel K","family":"Maclaren","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Pathology and Laboratory Medicine, University of Florida College of Medicine\u2008Gainesville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W","family":"Sleasman","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Pathology and Laboratory Medicine, University of Florida College of Medicine\u2008Gainesville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas J","family":"Barrett","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Pathology and Laboratory Medicine, University of Florida College of Medicine\u2008Gainesville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/40\/10\/1314\/358312\/40-10-1314.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/40\/10\/1314\/358312\/40-10-1314.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:16:57Z","timestamp":1667405817000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/40\/10\/1314\/7654\/CD5-B-Lymphocytes-in-High-Risk-Islet-Cell-Antibody"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1991,10,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.40.10.1314","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,10,1]]}}}