{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T19:02:36Z","timestamp":1778353356995,"version":"3.51.4"},"reference-count":0,"publisher":"American Diabetes Association","issue":"11","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,11,1]]},"abstract":"<jats:p>Spontaneously diabetic rats with remarkable polyuria, polyphagia, and polydipsia werediscovered in 1983 in an outbred colony of Long-Evans rats purchased from Charles River Canada in 1982. They have since been maintained at the Tokushima Research Institute (OtsukaPharmaceutical, Tokushima, Japan). A strain of rats (Long-Evans Tokushima Lean [LETL]) with diabetes was bred from these rats. The characteristic features of the disease in LETL rats are 1) sudden onset of polyuria, polyphagia, hyperglycemia, andweight loss; 2) no sex differences in the rate of onset or severity; 3) lymphocyte infiltration into islets followed by destruction of \u03b2-cells and disappearance of lymphocytes at the onset of diabetes; 4) no significant T lymphopenia; 5) lymphocyte infiltration into the salivary glands and lacrimal glands; and 6) at least two recessive genes involved in the pathogenesis of insulitis, one of which is closely linked with RT1u. These characteristics closely resemble those of human insulin-dependent diabetes mellitus (IDDM). Results suggest that the LETL rat is a useful animal model for analysisof genetic and immunologic factors relating to the pathogenesis of human IDDM.<\/jats:p>","DOI":"10.2337\/diab.40.11.1375","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:22:06Z","timestamp":1379611326000},"page":"1375-1381","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":49,"title":["New Inbred Strain of Long-Evans Tokushima Lean Rats With IDDM Without Lymphopenia"],"prefix":"10.2337","volume":"40","author":[{"given":"Kazuya","family":"Kawano","sequence":"first","affiliation":[{"name":"Tokushima Research Institute, Otsuka Pharmaceutical Company\u2008Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsukasa","family":"Hirashima","sequence":"additional","affiliation":[{"name":"Tokushima Research Institute, Otsuka Pharmaceutical Company\u2008Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehito","family":"Mori","sequence":"additional","affiliation":[{"name":"Tokushima Research Institute, Otsuka Pharmaceutical Company\u2008Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Saitoh","sequence":"additional","affiliation":[{"name":"Tokushima Research Institute, Otsuka Pharmaceutical Company\u2008Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Kurosumi","sequence":"additional","affiliation":[{"name":"Tokushima Research Institute, Otsuka Pharmaceutical Company\u2008Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Natori","sequence":"additional","affiliation":[{"name":"Tokushima Research Institute, Otsuka Pharmaceutical Company\u2008Tokushima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/40\/11\/1375\/337218\/40-11-1375.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/40\/11\/1375\/337218\/40-11-1375.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:17:03Z","timestamp":1667405823000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/40\/11\/1375\/10324\/New-Inbred-Strain-of-Long-Evans-Tokushima-Lean"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,11,1]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1991,11,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.40.11.1375","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,11,1]]}}}