{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:17:14Z","timestamp":1791944234930,"version":"4.3.4"},"reference-count":0,"publisher":"American Diabetes Association","issue":"6","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,6,1]]},"abstract":"<jats:p>In vivo \u03b2-cell function tests are used increasingly in humans during the preclinical phase of insulin-dependent diabetes mellitus (IDDM), but the severity of the \u03b2-cell loss responsible for the abnormalities seen in these tests is unknown. We have measured several physiological \u03b2-cell function tests\u2014fasting plasma glucose, glucose disappearance constant, fasting insulin, acute insulin responses to arginine (AIRarginine) and glucose (AIRglucose), and glucose potentiation of AIRarginine (\u2206 AIRarginine\/\u2206G) and two direct objective measurements (pancreatic insulin content [PIC] and quantitative \u03b2-cell mass)\u2014in adolescent male baboons (Papio anubis\/cyanocephalus). We have correlated in vivo measurements obtained within 3 days after the animals were killed with in vitro estimates of PIC and \u03b2-cell mass in 15 animals, (2 nondiabetic requiring insulin treatment and 13 after varying doses of streptozocin to induce degrees of \u03b2-cell damage ranging from normoglycemia to severe hyperglycemia). There was a strong linear correlation between \u03b2-cell mass and PIC (r = 0.79, P &amp;lt; 0.001). Physiological measures of \u03b2-cell function were significantly correlated with both PIC and \u03b2-cell mass. The correlations between physiological measures and \u03b2-cell mass were linear and intercepted the \u03b2-cell mass axis at 0.15\u20130.2 g, suggesting that in vivo measures of \u03b2-cell function approach 0 when there is still \u223c40\u201350% of the \u03b2-cell mass detectable histologically. With PIC, the linear correlations intercepted the axes close to 0. These findings provide considerable validity to the measurements of \u03b2-cell function used in preclinical IDDM in humans. Our data suggest that such physiological measurements give an accurate valid reflection of changes in \u03b2-cell mass and pancreatic insulin content.<\/jats:p>","DOI":"10.2337\/diab.40.6.673","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:22:06Z","timestamp":1379611326000},"page":"673-679","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":67,"title":["Correlations of In Vivo \u03b2-Cell Function Tests With \u03b2-Cell Mass and Pancreatic Insulin Content in Streptozocin-Administered Baboons"],"prefix":"10.2337","volume":"40","author":[{"given":"David K","family":"McCulloch","sequence":"first","affiliation":[{"name":"Veterans Affairs Medical Center, the Departments of Medicine, Physiology, and Biophysics, the Diabetes Endocrinology Research Center, University of Washington; and the Department of Veterans Affairs\u2008Seattle, Washington; and the Joslin Diabetes Center\u2008Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna J","family":"Koerker","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center, the Departments of Medicine, Physiology, and Biophysics, the Diabetes Endocrinology Research Center, University of Washington; and the Department of Veterans Affairs\u2008Seattle, Washington; and the Joslin Diabetes Center\u2008Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven E","family":"Kahn","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center, the Departments of Medicine, Physiology, and Biophysics, the Diabetes Endocrinology Research Center, University of Washington; and the Department of Veterans Affairs\u2008Seattle, Washington; and the Joslin Diabetes Center\u2008Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Bonner-Weir","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center, the Departments of Medicine, Physiology, and Biophysics, the Diabetes Endocrinology Research Center, University of Washington; and the Department of Veterans Affairs\u2008Seattle, Washington; and the Joslin Diabetes Center\u2008Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry P","family":"Palmer","sequence":"additional","affiliation":[{"name":"Veterans Affairs Medical Center, the Departments of Medicine, Physiology, and Biophysics, the Diabetes Endocrinology Research Center, University of Washington; and the Department of Veterans Affairs\u2008Seattle, Washington; and the Joslin Diabetes Center\u2008Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/40\/6\/673\/358457\/40-6-673.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/40\/6\/673\/358457\/40-6-673.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:18:49Z","timestamp":1667405929000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/40\/6\/673\/9298\/Correlations-of-In-Vivo-Cell-Function-Tests-With"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1991,6,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.40.6.673","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,6,1]]}}}