{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T22:48:46Z","timestamp":1771627726418,"version":"3.50.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"8","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,8,1]]},"abstract":"<jats:p>In this study, we administered constant intravenous infusions of human islet amyloid polypeptide (hIAPP) to conscious dogs during euglycemic glucose-clamp studies. The doses of hIAPP used (5 and 50 pmol \u00b7 kg\u22121 \u00b7 min\u22121) raised the circulating IAPP levels \u223c12- and 50-fold above basal levels, respectively. Studies were conducted at two different insulin infusion rates, resulting in steady-state plasma insulin levels of \u223c600 and 2800 pM. According to our results, the hIAPP infusions did not lead to any measurable change in the insulin-stimulated glucose disposal rate at either insulin infusion rate. Additionally, we observed no effect of IAPP on hepatic glucose production. Although we did not observe any effect of hIAPP on any of the aspects of glucose or insulin metabolism measured, we did find a consistent hypocalcemic effect of this peptide at the 50-pmol \u00b7 kg\u22121 \u00b7 min\u22121 infusion rate. Shortly after the onset of hIAPP infusion, serum calcium levels fell by 10\u201315% and remained at these levels throughout the course of the hIAPP infusion. In summary, 1) infusion of hIAPP at doses of 5 or 50 pmol \u00b7 kg\u22121 \u00b7 min\u22121 in conscious dogs raised the circulating IAPP level 12- to 50-fold above basal; 2) during these infusion studies, no effect of hIAPP was observed on any of the aspects of glucose or insulin homeostasis measured; 3) 50 pmol \u00b7 kg\u22121 \u00b7 min\u22121 hIAPP lead to a prompt reduction in plasma calcium concentrations with intravenous administration.<\/jats:p>","DOI":"10.2337\/diab.40.8.998","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:22:06Z","timestamp":1379611326000},"page":"998-1004","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":22,"title":["Lack of Effect of Islet Amyloid Polypeptide in Causing Insulin Resistance in Conscious Dogs During Euglycemic Clamp Studies"],"prefix":"10.2337","volume":"40","author":[{"given":"A A","family":"Kassir","sequence":"first","affiliation":[{"name":"Departments of Medicine and Surgery, University of California\u2008San Diego; and the Veterans Administration Medical Center, Division of Endocrinology and Metabolism\u2008La Jolla, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A K","family":"Upadhyay","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Surgery, University of California\u2008San Diego; and the Veterans Administration Medical Center, Division of Endocrinology and Metabolism\u2008La Jolla, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T J","family":"Lim","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Surgery, University of California\u2008San Diego; and the Veterans Administration Medical Center, Division of Endocrinology and Metabolism\u2008La Jolla, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A R","family":"Moossa","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Surgery, University of California\u2008San Diego; and the Veterans Administration Medical Center, Division of Endocrinology and Metabolism\u2008La Jolla, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Olefsky","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Surgery, University of California\u2008San Diego; and the Veterans Administration Medical Center, Division of Endocrinology and Metabolism\u2008La Jolla, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/40\/8\/998\/359076\/40-8-998.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/40\/8\/998\/359076\/40-8-998.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:19:25Z","timestamp":1667405965000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/40\/8\/998\/7960\/Lack-of-Effect-of-Islet-Amyloid-Polypeptide-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,8,1]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1991,8,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.40.8.998","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,8,1]]}}}