{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T11:23:33Z","timestamp":1698578613037},"reference-count":0,"publisher":"American Diabetes Association","issue":"7","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1992,7,1]]},"abstract":"<jats:p>A role for heat shock proteins (HSPs) in autoimmunity has recently been suggested by several authors. Autoantibodies against HSPs have been associated with such autoimmune diseases as systemic lupus erythematosus, polymyositis, and the NOD mouse model of diabetes. Moreover, genes for the major 70,000-Mr HSP (HSP70) are located within the MHC. To investigate a potential association of an HSP70\u20132 gene polymorphism with insulin-dependent diabetes mellitus (IDDM), we analyzed restriction-fragment\u2013length polymorphism (RFLP) of this gene in 29 families with one or more member affected by IDDM. With the enzyme PstI, as reported previously, two HSP70\u20132 alleles of 8.5- and 9.0-kb were found. The 8.5-kb allele was found more frequently on diabetic haplotypes compared with control haplotypes (41 of 66 [62%] vs. 20 of 46 [43%], P = 0.03). This association was due to the conservation of alleles on extended haplotypes we previously reported to be associated with diabetes on initial analysis of families. Twenty-three of 26 diabetic DR3 haplotypes and 3 of 3 normal DR3 haplotypes and all instances of [HLA-B8, SC01, DR3] and [HLA-B18, F1C30, DR3] had the 8.5-kb allele, whereas 0 of 9 normal DR2 haplotypes and 0 of 2 diabetic DR2 haplotypes had the 8.5-kb allele (P = 8 \u00d7 10\u22127 DR3 vs. DR2 haplotypes). The alleles were equally distributed among DR4 haplotypes. Our studies indicate that the 8.5-kb allele is part of [HLA-B8, SC01, DR3] and [HLA-B18, F1C30, DR3] haplotypes, and the 9.0-kb allele is associated with DR2 but no independent association (greater than DR association) is found between HSP70\u20132 alleles and diabetes.<\/jats:p>","DOI":"10.2337\/diab.41.7.788","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:22:06Z","timestamp":1379611326000},"page":"788-791","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":6,"title":["No Independent Association Between <i>HSP70<\/i> Gene Polymorphism and IDDM"],"prefix":"10.2337","volume":"41","author":[{"given":"Alberto","family":"Pugliese","sequence":"first","affiliation":[{"name":"Joslin Diabetes Center\u2008Boston\u2008Brigham and Womens Hospital\u2008Boston\u2008The Center for Blood Research, Harvard Medical School\u2008Boston, Massachusetts\u2008Clinica Medica B, University of Palermo\u2008Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zuheir L","family":"Awdeh","sequence":"additional","affiliation":[{"name":"Joslin Diabetes Center\u2008Boston\u2008Brigham and Womens Hospital\u2008Boston\u2008The Center for Blood Research, Harvard Medical School\u2008Boston, Massachusetts\u2008Clinica Medica B, University of Palermo\u2008Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Galluzzo","sequence":"additional","affiliation":[{"name":"Joslin Diabetes Center\u2008Boston\u2008Brigham and Womens Hospital\u2008Boston\u2008The Center for Blood Research, Harvard Medical School\u2008Boston, Massachusetts\u2008Clinica Medica B, University of Palermo\u2008Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmond J","family":"Yunis","sequence":"additional","affiliation":[{"name":"Joslin Diabetes Center\u2008Boston\u2008Brigham and Womens Hospital\u2008Boston\u2008The Center for Blood Research, Harvard Medical School\u2008Boston, Massachusetts\u2008Clinica Medica B, University of Palermo\u2008Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chester A","family":"Alper","sequence":"additional","affiliation":[{"name":"Joslin Diabetes Center\u2008Boston\u2008Brigham and Womens Hospital\u2008Boston\u2008The Center for Blood Research, Harvard Medical School\u2008Boston, Massachusetts\u2008Clinica Medica B, University of Palermo\u2008Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George S","family":"Eisenbarth","sequence":"additional","affiliation":[{"name":"Joslin Diabetes Center\u2008Boston\u2008Brigham and Womens Hospital\u2008Boston\u2008The Center for Blood Research, Harvard Medical School\u2008Boston, Massachusetts\u2008Clinica Medica B, University of Palermo\u2008Palermo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/41\/7\/788\/359609\/41-7-788.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/41\/7\/788\/359609\/41-7-788.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:21:24Z","timestamp":1667406084000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/41\/7\/788\/8020\/No-Independent-Association-Between-HSP70-Gene"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,7,1]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1992,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.41.7.788","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,7,1]]}}}