{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T07:22:15Z","timestamp":1695972135268},"reference-count":0,"publisher":"American Diabetes Association","issue":"1","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,1,1]]},"abstract":"<jats:p>In a model of congenic and intra-MHC recombinant rat strains, the differential role of various histocompatibility antigens in renal subcapsular transplantation of purified islets of Langerhans isevaluated. Class I MHC antigens of the RT1.A region, expressed on the endocrine cells of the islets themselves, do not induce graft rejection on their own. MHC class I antigens as encoded by the RT1.C region do not induce rejection either. MHC class II antigens as encoded by the RT1.B\/D region are not expressed on the endocrine pancreas, not even during rejection. Although interstitial dendritic cells situated within the islets expess these antigens, an isolated RT1. B\/D incompatibility of islets is associated with prolonged survival in contrast to rapid rejection of fully MHC-mismatched grafts. Unlike other organs, islets matched for all MHC antigens, but incompatible at minor histocompatibility antigens, undergo rejection early after transplantation.<\/jats:p>","DOI":"10.2337\/diab.42.1.90","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:22:06Z","timestamp":1379611326000},"page":"90-97","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":7,"title":["The Role of Histocompatibility Antigens in Transplantation of Isolated Islets of Langerhans in the Rat"],"prefix":"10.2337","volume":"42","author":[{"given":"Wolfgang F A","family":"Hiller","sequence":"first","affiliation":[{"name":"Department of Abdominal and Transplantation Surgery, Hannover; and the Department of Anatomy V, Medical School\u2008Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birte","family":"Steiniger","sequence":"additional","affiliation":[{"name":"Department of Abdominal and Transplantation Surgery, Hannover; and the Department of Anatomy V, Medical School\u2008Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Klempnauer","sequence":"additional","affiliation":[{"name":"Department of Abdominal and Transplantation Surgery, Hannover; and the Department of Anatomy V, Medical School\u2008Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/42\/1\/90\/359807\/42-1-90.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/42\/1\/90\/359807\/42-1-90.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:22:19Z","timestamp":1667406139000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/42\/1\/90\/8398\/The-Role-of-Histocompatibility-Antigens-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.42.1.90","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1,1]]}}}