{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:42:25Z","timestamp":1773758545733,"version":"3.50.1"},"reference-count":0,"publisher":"American Diabetes Association","issue":"10","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,10,1]]},"abstract":"<jats:p>Because of islet allograft rejection, nonimmunosuppressed pancreatic islet allotransplantation has been unsuccessful for the treatment of type I diabetes. The role of major histocompatibility complex class I antigen expression on islet allograft survival was evaluated with the use of mice homozygous for a \u03b22-microglobulin gene disruption. These mice express little if any functional major histocompatibility complex class I antigen. When these major histocompatibility complex class I-deficient islets were used as donors in an allogenic murine transplantation model, islet allograft survival was markedly prolonged. These results demonstrate a major importance for the alloresponse directed against major histocompatibility complex class I antigen.<\/jats:p>","DOI":"10.2337\/diab.42.10.1520","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:22:06Z","timestamp":1379611326000},"page":"1520-1527","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":25,"title":["Major Histocompatibility Complex Class I Deficiency Prolongs Islet Allograft Survival"],"prefix":"10.2337","volume":"42","author":[{"given":"Robert W","family":"Osorio","sequence":"first","affiliation":[{"name":"Liver Transplant Division, Department of Surgery, University of California\u2008San Francisco, California\u2008Whitehead Institute For Biomedical Research and Department of Biology, Massachusetts Institute of Technology\u2008Cambridge, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy L","family":"Ascher","sequence":"additional","affiliation":[{"name":"Liver Transplant Division, Department of Surgery, University of California\u2008San Francisco, California\u2008Whitehead Institute For Biomedical Research and Department of Biology, Massachusetts Institute of Technology\u2008Cambridge, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudolf","family":"Jaenisch","sequence":"additional","affiliation":[{"name":"Liver Transplant Division, Department of Surgery, University of California\u2008San Francisco, California\u2008Whitehead Institute For Biomedical Research and Department of Biology, Massachusetts Institute of Technology\u2008Cambridge, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris E","family":"Freise","sequence":"additional","affiliation":[{"name":"Liver Transplant Division, Department of Surgery, University of California\u2008San Francisco, California\u2008Whitehead Institute For Biomedical Research and Department of Biology, Massachusetts Institute of Technology\u2008Cambridge, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P","family":"Roberts","sequence":"additional","affiliation":[{"name":"Liver Transplant Division, Department of Surgery, University of California\u2008San Francisco, California\u2008Whitehead Institute For Biomedical Research and Department of Biology, Massachusetts Institute of Technology\u2008Cambridge, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G","family":"Stock","sequence":"additional","affiliation":[{"name":"Liver Transplant Division, Department of Surgery, University of California\u2008San Francisco, California\u2008Whitehead Institute For Biomedical Research and Department of Biology, Massachusetts Institute of Technology\u2008Cambridge, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/42\/10\/1520\/359697\/42-10-1520.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/42\/10\/1520\/359697\/42-10-1520.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:22:31Z","timestamp":1667406151000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/42\/10\/1520\/8256\/Major-Histocompatibility-Complex-Class-I"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1993,10,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.42.10.1520","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,10,1]]}}}