{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:10:22Z","timestamp":1762161022175},"reference-count":0,"publisher":"American Diabetes Association","issue":"7","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,7,1]]},"abstract":"<jats:p>Cytokines have been regarded as effector molecules responsible for +-cell death and major histocompatibility complex hyperexpression in endocrine pancreas of type I diabetes. However, the mechanism that results in +-cell\u2013selective destruction has not been elucidated. We demonstrated in this study, using cell lines of transformed mouse +-cells and \u03b1-cells, that only pancreatic +-cells but not \u03b1-cells produced tumor necrosis factor-\u03b1 when exposed to interleukin-1 +. Northern blot analysis confirmed the +-cell-selective expression of tumor necrosis factor-\u03b1 mRNA. Interleukin-1 + also provoked tumor necrosis factor-\u03b1 mRNA expression in vitro by normal mouse islet cells. Because tumor necrosis factor-\u03b1 has been shown to potentiate +-cell cytotoxicity of interleukin-1 and interferon-gamma, tumor necrosis factor-\u03b1 produced in situ by +-cells might be self-destructive. In fact, a low dose of interleukin-1 + in combination with a low dose of interferon-gamma preferentially injured +-cells. Hence endogenous tumor necrosis factor-\u03b1 production by +-cells may be involved in +-cell\u2013selective destruction in type 1 diabetes.<\/jats:p>","DOI":"10.2337\/diab.42.7.1026","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:22:06Z","timestamp":1379611326000},"page":"1026-1031","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":15,"title":["Pancreatic \u03b2-Cell\u2013Selective Production of Tumor Necrosis Factor-\u03b1 Induced by Interleukin-1"],"prefix":"10.2337","volume":"42","author":[{"given":"Kentaro","family":"Yamada","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine and Department of Parasitology, Kurume University School of Medicine\u2008Kurume, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Takane","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine and Department of Parasitology, Kurume University School of Medicine\u2008Kurume, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Otabe","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine and Department of Parasitology, Kurume University School of Medicine\u2008Kurume, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chizuko","family":"Inada","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine and Department of Parasitology, Kurume University School of Medicine\u2008Kurume, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Inoue","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine and Department of Parasitology, Kurume University School of Medicine\u2008Kurume, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyohei","family":"Nonaka","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Medicine and Department of Parasitology, Kurume University School of Medicine\u2008Kurume, Fukuoka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/42\/7\/1026\/360155\/42-7-1026.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/42\/7\/1026\/360155\/42-7-1026.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:23:56Z","timestamp":1667406236000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/42\/7\/1026\/8385\/Pancreatic-Cell-Selective-Production-of-Tumor"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7,1]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1993,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.42.7.1026","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7,1]]}}}