{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T05:19:39Z","timestamp":1768799979772,"version":"3.49.0"},"reference-count":0,"publisher":"American Diabetes Association","issue":"10","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,10,1]]},"abstract":"<jats:p>To evaluate the role of nitric oxide (NO) in diabetic hyperfiltration, renal hemodynamic changes and changes in urinary excretion of NO2\/NO3 in response to the NO inhibitor nitro-L-arginine methyl ester (L-NAME) and the NO-donating agent glyceryl trinitrate (GTN) were investigated in conscious streptozocin-induced diabetic (D) and age-matched control (C) rats. In all experiments, D rats demonstrated increased glomerular filtration rate (GFR), renal plasma flow (RPF), polyuria, and an increased urinary sodium excretion when compared with C rats. An intravenous bolus of low-dose L-NAME (1 mg\/kg body wt) increased modestly systolic blood pressure (sBP) in C rats but had no effect on sBP in D rats. L-NAME induced a marked decrease in GFR and RPF in D rats with no change in filtration fraction (FF). In C rats, no change in GFR was observed, and RPF decreased, resulting in a rise in FF. A supramaximal dose of L-NAME (10 mg\/kg body wt) increased sBP in C and D rats to a similar degree. With high-dose L-NAME, GFR decreased in D but not in C rats. There was a greater decrease in RPF in D rats when compared with C animals. An intravenous infusion of GTN induced a modest decrease in sBP in both C and D rats (P &amp;lt; 0.01). There were no changes in GFR and RPF in D rats, but in the C group, GTN increased RPF (P &amp;lt; 0.05) with a tendency for a rise in GFR (P = 0.09). Basal urinary NO2\/NO3 excretion was increased in D rats in all experiments. A decrease in urinary NO2\/NO3 levels was observed after low-dose L-NAME in D rats, with a similar trend after high-dose L-NAME. NO such changes were observed in C rats. GTN infusion had no effect on urinary NO2\/NO3 excretion in D rats but increased urinary NO2\/NO3 levels in C rats to levels that were not statistically different from those in D rats. These studies suggest that increased renal production and\/or sensitivity to endothelium-derived relaxing factor\/NO may play a role in the genesis of diabetic hyperfiltration.<\/jats:p>","DOI":"10.2337\/diab.43.10.1190","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:22:06Z","timestamp":1379611326000},"page":"1190-1197","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":60,"title":["Role of Endothelium-Derived Nitric Oxide in the Pathogenesis of the Renal Hemodynamic Changes of Experimental Diabetes"],"prefix":"10.2337","volume":"43","author":[{"given":"Radko","family":"Komers","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Melbourne, Heidelberg Repatriation Hospital\u2008West Heidelberg, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terri J","family":"Allen","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Melbourne, Heidelberg Repatriation Hospital\u2008West Heidelberg, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E","family":"Cooper","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Melbourne, Heidelberg Repatriation Hospital\u2008West Heidelberg, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/43\/10\/1190\/336796\/43-10-1190.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/43\/10\/1190\/336796\/43-10-1190.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:24:43Z","timestamp":1667406283000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/43\/10\/1190\/8221\/Role-of-Endothelium-Derived-Nitric-Oxide-in-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,10,1]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1994,10,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.43.10.1190","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,10,1]]}}}