{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T10:30:29Z","timestamp":1786703429774,"version":"build-2736575974"},"reference-count":0,"publisher":"American Diabetes Association","issue":"4","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,4,1]]},"abstract":"<jats:p>Although both kidney and pancreas transplantation can restore renal and pancreatic endocrine functions, the accompanying immunosuppression may cause diminished glucose tolerance in some individuals. Therefore, we determined to what extent pancreas transplantation itself and the triple immunosuppressive therapy used in pancreas transplant recipients have adverse effects on insulin secretory reserve. \u03b2-cell secretory reserve was assessed by the method of glucose potentiation of arginine-induced insulin secretion in 25 normoglycemic pancreas recipients, 12 nondiabetic kidney recipients using the same immunosuppressive therapy, 3 psoriasis patients treated long term with cyclosporine, 5 arthritis patients treated long term with prednisone, and their respective sex-, age-, and body mass index-matched control subjects. Levels of fasting glucose, HbA1c, and glucose disappearance rates were normal in all subjects. During the glucose potentiation study, pancreas recipients had significantly less insulin secretion than control subjects (maximal acute response [ARmax] = 1,083 \u00b1 93% vs. 3,938 \u00b1 355%, P &amp;lt; 0.001). Insulin responses were also decreased in kidney recipients (ARmax = 2,296 \u00b1 290%) vs. control subjects (4,691 \u00b1 554%, P = 0.001) and in psoriasis patients treated with cyclosporine (ARmax = 2,153 \u00b1 390%) vs. control subjects (3,962 \u00b1 88%, P = 0.011), but not as extreme as that seen in pancreas recipients. No abnormalities were observed in arthritis patients treated with steroids. We conclude that normoglycemic pancreas and kidney transplant recipients receiving triple immunosuppressive therapy have diminished \u03b2-cell secretory reserve. Because this defect was present in psoriasis patients treated long term with cyclosporine, but not in arthritis patients treated long term with prednisone, this adverse effect was probably caused in part by cyclosporine.<\/jats:p>","DOI":"10.2337\/diab.43.4.593","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:22:06Z","timestamp":1379611326000},"page":"593-598","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":38,"title":["Diminished Insulin Secretory Reserve in Diabetic Pancreas Transplant and Nondiabetic Kidney Transplant Recipients"],"prefix":"10.2337","volume":"43","author":[{"given":"Adrian U","family":"Teuscher","sequence":"first","affiliation":[{"name":"Diabetes, Endocrinology, and Metabolism Division, Department of Medicine, University of Minnesota Medical School\u2008Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R","family":"Seaquist","sequence":"additional","affiliation":[{"name":"Diabetes, Endocrinology, and Metabolism Division, Department of Medicine, University of Minnesota Medical School\u2008Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R Paul","family":"Robertson","sequence":"additional","affiliation":[{"name":"Diabetes, Endocrinology, and Metabolism Division, Department of Medicine, University of Minnesota Medical School\u2008Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/43\/4\/593\/337008\/43-4-593.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/43\/4\/593\/337008\/43-4-593.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:25:42Z","timestamp":1667406342000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/43\/4\/593\/9568\/Diminished-Insulin-Secretory-Reserve-in-Diabetic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,4,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.43.4.593","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,4,1]]}}}