{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:28:58Z","timestamp":1761895738782},"reference-count":0,"publisher":"American Diabetes Association","issue":"7","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1994,7,1]]},"abstract":"<jats:p>The effect of hyperglycemia on in vivo adipose tissue metabolism was studied with microdialysis in seven lean patients with insulin-dependent diabetes mellitus (IDDM) receiving a constant infusion of insulin (36 pmol\u00b7m\u22122 \u00b7 min\u22121). Glucose was infused in a randomized fashion to maintain either a lower glucose level (6.6 \u00b1 0.3 mM, mean \u00b1 SE) or hyperglycemia (11.8 \u00b1 0.8 mM) for 3 h. For insulin concentrations of 84 \u00b1 12 and 96 \u00b1 12 pM, hyperglycemia (11.8 \u00b1 0.8 mM) did not alter the plasma glycerol or lactate levels significantly but resulted in a significant (P &amp;lt; 0.0001) increase in plasma free fatty acid levels (0.49 \u00b1 0.13 vs. 0.32 \u00b1 0.08 mM). Plasma catecholamine levels were unchanged during hyperglycemia. Interstitial glycerol concentrations, measured in abdominal subcutaneous adipose tissue as an index of lipolysis, were not significantly influenced by hyperglycemia when compared with concentrations at the lower glucose level (92 \u00b1 30 vs. 106 \u00b1 18 \u00b5M). Moreover, hyperglycemia did not change abdominal adipose interstitial lactate levels significantly (1,248 \u00b1 174 vs. 1,351 \u00b1 159 microM during euglycemia). It may be concluded that hyperglycemia has no independent antilipolytic effect in IDDM subjects. Furthermore, in these patients, hyperglycemia gives no further lactate production in the subcutaneous adipose tissue in the presence of low physiological insulin levels.<\/jats:p>","DOI":"10.2337\/diab.43.7.866","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:22:06Z","timestamp":1379611326000},"page":"866-870","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":2,"title":["Effects of Hyperglycemia on In Vivo Adipose Tissue Metabolism Studied With Microdialysis in IDDM Subjects"],"prefix":"10.2337","volume":"43","author":[{"given":"Ter\u00e9 M","family":"van der Merwe","sequence":"first","affiliation":[{"name":"University of the Witwatersrand, Johannesburg General Hospital, Johannesburg\u2008South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Eklund","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Goteborg, Sahlgren's Hospital\u2008G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per-Anders E","family":"Jansson","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Goteborg, Sahlgren's Hospital\u2008G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter N","family":"L\u00f6nnroth","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Goteborg, Sahlgren's Hospital\u2008G\u00f6teborg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/43\/7\/866\/360757\/43-7-866.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/43\/7\/866\/360757\/43-7-866.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:26:08Z","timestamp":1667406368000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/43\/7\/866\/8499\/Effects-of-Hyperglycemia-on-In-Vivo-Adipose-Tissue"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,7,1]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1994,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.43.7.866","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,7,1]]}}}