{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:53:07Z","timestamp":1792173187640,"version":"4.4.0"},"reference-count":0,"publisher":"American Diabetes Association","issue":"5","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1995,5,1]]},"abstract":"<jats:p>We tested 32 routine clinical parameters for their ability to discriminate between a high risk and a low risk of non-insulin-dependent diabetes mellitus (NIDDM) within 5\u20137 years after pregnancies complicated by gestational diabetes mellitus (GDM). Latino women (n = 671) with GDM who did not have diabetes 4\u201316 weeks after delivery returned for at least one 75-g oral glucose tolerance test (OGTT) within 7.5 years. Multivariate analysis was used to identify parameters ascertained during or immediately after the index pregnancy that were independently associated with the development of diabetes during follow-up. Life table analysis revealed a 47% cumulative incidence rate of NIDDM 5 years after delivery for this cohort of patients who did not have diabetes at the initial postpartum examination. Four variables were identified as independent predictors of NIDDM: the area under the OGTT glucose curve at 4\u201316 weeks postpartum, the gestational age at the time of diagnosis of GDM, the area under the OGTT glucose curve during pregnancy, and the highest fasting serum glucose concentration during pregnancy. Examination of relative risks (RRs) of NIDDM between the highest and lowest quartiles of the cohort for each variable, adjusted for the other three variables, revealed that the postpartum OGTT provided the best discrimination between high-risk and low-risk individuals (adjusted RR = 11.5 [95% confidence interval 4.5\u201329.1] compared with adjusted RRs of only 0.5\u20132.5 for the other three variables). Women who met World Health Organization criteria for impaired glucose tolerance at the early postpartum examination had a 5-year unadjusted 80% risk of diabetes, which was much higher than the risk of NIDDM that has been reported for Latino people with impaired glucose tolerance who were not selected for a history of GDM. Our findings indicate that postpartum glucose tolerance testing is superior to other routine clinical parameters in defining the risk of NIDDM within 5\u20137 years after pregnancies complicated by GDM. Furthermore, a history of GDM appears to impart a specific risk for NIDDM that cannot be explained by the degree of glucose tolerance observed when patients are not pregnant.<\/jats:p>","DOI":"10.2337\/diab.44.5.586","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T17:22:06Z","timestamp":1379611326000},"page":"586-591","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":218,"title":["Predicting Future Diabetes in Latino Women With Gestational Diabetes: Utility of Early Postpartum Glucose Tolerance Testing"],"prefix":"10.2337","volume":"44","author":[{"given":"Siri L","family":"Kjos","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology, School of Medicine, University of Southern California\u2008Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth K","family":"Peters","sequence":"additional","affiliation":[{"name":"Preventive Medicine, School of Medicine, University of Southern California\u2008Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anny","family":"Xiang","sequence":"additional","affiliation":[{"name":"Preventive Medicine, School of Medicine, University of Southern California\u2008Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia A","family":"Henry","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, School of Medicine, University of Southern California\u2008Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Montoro","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology, School of Medicine, University of Southern California\u2008Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A","family":"Buchanan","sequence":"additional","affiliation":[{"name":"Departments of Medicine, School of Medicine, University of Southern California\u2008Los Angeles, California"},{"name":"Obstetrics and Gynecology, School of Medicine, University of Southern California\u2008Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/44\/5\/586\/337022\/44-5-586.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/44\/5\/586\/337022\/44-5-586.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:27:55Z","timestamp":1667406475000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/44\/5\/586\/8778\/Predicting-Future-Diabetes-in-Latino-Women-With"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,5,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.44.5.586","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,5,1]]}}}