{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:52:35Z","timestamp":1787025155871,"version":"build-2736575974"},"reference-count":0,"publisher":"American Diabetes Association","issue":"1","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,1,1]]},"abstract":"<jats:p>Amylin, a 37-amino acid peptide hormone co-secreted with insulin, potently governs the rate of gastric emptying. Hypoglycemia, in the absence of agents such as amylin, is reported to accelerate gastric emptying. We asked whether hypoglycemia had a similar action on gastric emptying in the presence of amylin. In preliminary experiments using a phenol red gavage technique in fasted SD rats, we showed that insulin administration accelerated gastric emptying in a dosage-dependent manner. This acceleration was totally prevented by coadministration of glucose in dosages that prevented a change in plasma glucose, indicating that insulin per se did not affect gastric emptying. The effect on gastric emptying of hypoglycemia induced by a 5 mU\/min insulin infusion (t = 5\u201390 min) was assessed in conscious rats continuously infused with amylin (50 pmol \u00b7 kg\u22121 \u00b7 min\u22121; t = \u221230 to 90 min). Gastric emptying was indicated by the appearance in plasma of label from 3-O-methyl-[3H]glucose gavaged at t = 0 min. Label appearance was markedly inhibited in rats preinfused with amylin (84% reduced vs. saline controls at t = 30min), indicating amylin inhibition of gastric emptying. In amylin-treated rats that were subsequently infused with insulin, gavaged label abruptly appeared in plasma when plasma glucose had fallen to 2.1 \u00b1 0.1 mmol\/1 (at t \u2245 45 min), consistent with a reversal by hypoglycemia of amylin's inhibition of gastric emptying. These data support the idea of a central \u201cfail-safe\u201d mechanism whereby hypoglycemia can override the slowing of gastric emptying by amylin.<\/jats:p>","DOI":"10.2337\/diab.47.1.93","type":"journal-article","created":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T13:42:54Z","timestamp":1379598174000},"page":"93-97","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":39,"title":["Hypoglycemia Overrides Amylin-Mediated Regulation of Gastric Emptying in Rats"],"prefix":"10.2337","volume":"47","author":[{"given":"Bronislava R","family":"Gedulin","sequence":"first","affiliation":[{"name":"Amylin Pharmaceuticals\u2008San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A","family":"Young","sequence":"additional","affiliation":[{"name":"Amylin Pharmaceuticals\u2008San Diego, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/47\/1\/93\/363254\/47-1-93.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/47\/1\/93\/363254\/47-1-93.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T12:34:38Z","timestamp":1667392478000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/47\/1\/93\/9955\/Hypoglycemia-Overrides-Amylin-Mediated-Regulation"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,1,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diab.47.1.93","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,1,1]]}}}