{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:00:00Z","timestamp":1791273600525,"version":"4.1.0"},"reference-count":117,"publisher":"American Diabetes Association","issue":"1","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,1,1]]},"abstract":"<jats:p>Nutrient homeostasis is known to be regulated by pancreatic islet tissue. The function of islet \u03b2-cells is controlled by a glucose sensor that operates at physiological glucose concentrations and acts in synergy with signals that integrate messages originating from hypothalamic neurons and endocrine cells in gut and pancreas. Evidence exists that the extrapancreatic cells producing and secreting these (neuro)endocrine signals also exhibit a glucose sensor and an ability to integrate nutrient and (neuro)hormonal messages. Similarities in these cellular and molecular pathways provide a basis for a network of coordinated functions between distant cell groups, which is necessary for an appropriate control of nutrient homeostasis. The glucose sensor seems to be a fundamental component of these control mechanisms. Its molecular characterization is most advanced in pancreatic \u03b2-cells, with important roles for glucokinase and mitochondrial oxidative fluxes in the regulation of ATP-sensitive K+ channels. Other glucose-sensitive cells in the endocrine pancreas, hypothalamus, and gut were found to share some of these molecular characteristics. We propose that similar metabolic signaling pathways influence the function of pancreatic \u03b1-cells, hypothalamic neurons, and gastrointestinal endocrine and neural cells.<\/jats:p>","DOI":"10.2337\/diabetes.50.1.1","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:04:22Z","timestamp":1173207862000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":329,"title":["Glucose Sensing in Pancreatic \u03b2-Cells"],"prefix":"10.2337","volume":"50","author":[{"given":"Frans C.","family":"Schuit","sequence":"first","affiliation":[{"name":"From the Diabetes Research Center, Faculty of Medicine, Vrije Universiteit Brussel, Brussels, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Huypens","sequence":"additional","affiliation":[{"name":"From the Diabetes Research Center, Faculty of Medicine, Vrije Universiteit Brussel, Brussels, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Heimberg","sequence":"additional","affiliation":[{"name":"From the Diabetes Research Center, Faculty of Medicine, Vrije Universiteit Brussel, Brussels, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Pipeleers","sequence":"additional","affiliation":[{"name":"From the Diabetes Research Center, Faculty of Medicine, Vrije Universiteit Brussel, Brussels, Belgium."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031206582419000_REF1","doi-asserted-by":"crossref","unstructured":"Matschinsky FM, Glaser B, Magnuson MA: Pancreatic \u03b2-cell glucokinase: closing the gap between theoretical concepts and experimental realities. 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Am J Physiol\u2008221: 1596-1603, 1971","DOI":"10.1152\/ajplegacy.1971.221.6.1596"},{"key":"2022031206582419000_REF104","doi-asserted-by":"crossref","unstructured":"Jansson L, Hellerstrom C: Glucose-induced changes in pancreatic islet blood flow mediated by central nervous system. Am J Physiol\u2008251: E644-E647, 1986","DOI":"10.1152\/ajpendo.1986.251.6.E644"},{"key":"2022031206582419000_REF105","doi-asserted-by":"crossref","unstructured":"Henquin JC, Nenquin M: The muscarinic receptor subtype in mouse pancreatic B-cells. FEBS Lett\u2008236: 89-92, 1988","DOI":"10.1016\/0014-5793(88)80290-4"},{"key":"2022031206582419000_REF106","doi-asserted-by":"crossref","unstructured":"Yada T, Sakurada M, Ihida K, Nakata M, Murata F, Arimura A, Kikuchi M: Pituitary adenylate cyclase activating polypeptide is an extraordinarily potent intra-pancreatic regulator of insulin secretion from islet \u03b2-cells. J Biol Chem\u2008269: 1290-1293, 1994","DOI":"10.1016\/S0021-9258(17)42256-3"},{"key":"2022031206582419000_REF107","doi-asserted-by":"crossref","unstructured":"Filipsson K, Sundler F, Hannibal J, Ahren B: PACAP and PACAP receptors in insulin producing tissues: localization and effects. Regul Pept\u200874: 167-175, 1998","DOI":"10.1016\/S0167-0115(98)00037-8"},{"key":"2022031206582419000_REF108","doi-asserted-by":"crossref","unstructured":"Straub SG, Sharp GW: A wortmannin-sensitive signal transduction pathway is involved in the stimulation of insulin release by vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide. J Biol Chem\u2008271: 1660-1668, 1996","DOI":"10.1074\/jbc.271.3.1660"},{"key":"2022031206582419000_REF109","doi-asserted-by":"crossref","unstructured":"Edwards AV, Bloom SR, Ghatei MA: Pancreatic endocrine responses to the peptides VIP and PACAP in the conscious calf. Exp Physiol\u200882: 717-727, 1997","DOI":"10.1113\/expphysiol.1997.sp004060"},{"key":"2022031206582419000_REF110","doi-asserted-by":"crossref","unstructured":"Havel PJ, Dunning BE, Verchere CB, Baskin DG, O'Dorisio T, Taborsky GJ Jr: Evidence that vasoactive intestinal polypeptide is a parasympathetic neurotransmitter in the endocrine pancreas in dogs. Regul Pept\u200871: 163-170, 1997","DOI":"10.1016\/S0167-0115(97)01014-8"},{"key":"2022031206582419000_REF111","doi-asserted-by":"crossref","unstructured":"De Vos A, Heimberg H, Quartier E, Huypens P, Bouwens L, Pipeleers D, Schuit F: Human and rat \u03b2-cells differ in glucose transporter but not in glucokinase gene expression. J Clin Invest\u200896: 2489-2495, 1995","DOI":"10.1172\/JCI118308"},{"key":"2022031206582419000_REF112","doi-asserted-by":"crossref","unstructured":"Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O'Rahilly S: Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature\u2008387: 903-908, 1997","DOI":"10.1038\/43185"},{"key":"2022031206582419000_REF113","unstructured":"Habener JF, Stoffers DA: A newly discovered role of transcription factors involved in pancreas development and the pathogenesis of diabetes mellitus. Proc Assoc Am Physicians\u2008110: 12-21, 1998"},{"key":"2022031206582419000_REF114","doi-asserted-by":"crossref","unstructured":"Erickson JC, Clegg KE, Palmiter RD: Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. 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