{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:25:40Z","timestamp":1779150340709,"version":"3.51.4"},"reference-count":0,"publisher":"American Diabetes Association","issue":"suppl_1","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,2,1]]},"abstract":"<jats:p>Insulin receptor (IR)-deficient pups rapidly become hyperglycemic and hyperinsulinemic and die of diabetic ketoacidosis within a few days. Immunocytochemical analysis of the endocrine pancreas revealed that IR deficiency did not alter islet morphology or the number of beta-, alpha-, delta-, and pancreatic polypeptide (PP) cells. The lack of IR did not result in major changes in the expression of islet hormone genes or of beta-cell-specific marker genes encoding pancreas duodenum homeobox-containing transcription factor-1 (PDX-1), glucokinase (GCK), and GLUT2, as shown by reverse transcriptase-polymerase chain reaction analysis. The serum glucagon levels in IR-deficient and nondiabetic littermates were comparable. Finally, total insulin content in the pancreas of IR-deficient pups was gradually depleted, indicating sustained insulin secretion, not compensated for by increased insulin biosynthesis. These findings are discussed in light of recent results suggesting a role of IR in beta-cell function.<\/jats:p>","DOI":"10.2337\/diabetes.50.2007.s146","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:04:22Z","timestamp":1173207862000},"page":"S146","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":13,"title":["Endocrine pancreas in insulin receptor-deficient mouse pups."],"prefix":"10.2337","volume":"50","author":[{"given":"M","family":"Jackerott","sequence":"first","affiliation":[{"name":"Department of Genetics, Development and Molecular Pathology, ICGM, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 257, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Baudry","sequence":"additional","affiliation":[{"name":"Department of Genetics, Development and Molecular Pathology, ICGM, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 257, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Lamothe","sequence":"additional","affiliation":[{"name":"Department of Genetics, Development and Molecular Pathology, ICGM, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 257, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Bucchini","sequence":"additional","affiliation":[{"name":"Department of Genetics, Development and Molecular Pathology, ICGM, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 257, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Jami","sequence":"additional","affiliation":[{"name":"Department of Genetics, Development and Molecular Pathology, ICGM, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 257, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R L","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Genetics, Development and Molecular Pathology, ICGM, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale Unit 257, Paris, France."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/50\/suppl_1\/S146\/533136\/s146.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/50\/suppl_1\/S146\/533136\/s146.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:09:34Z","timestamp":1667405374000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/50\/suppl_1\/S146\/11595\/Endocrine-pancreas-in-insulin-receptor-deficient"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2,1]]},"references-count":0,"journal-issue":{"issue":"suppl_1","published-print":{"date-parts":[[2001,2,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diabetes.50.2007.s146","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2,1]]}}}