{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:11:46Z","timestamp":1791295906152,"version":"4.1.0"},"reference-count":0,"publisher":"American Diabetes Association","issue":"suppl_1","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,2,1]]},"abstract":"<jats:p>The GK rat model of type 2 diabetes is especially convenient to dissect the pathogenic mechanism necessary for the emergence of overt diabetes because all adult rats obtained in our department (GK\/Par colony) to date have stable basal mild hyperglycemia and because overt diabetes is preceded by a period of normoglycemia, ranging from birth to weaning. The purpose of this article is to sum up the information so far available related to the biology of the beta-cell in the GK\/Par rat. In terms of beta-cell function, there is no major intrinsic secretory defect in the prediabetic GK\/Par beta-cell, and the lack of beta-cell reactivity to glucose (which reflects multiple intracellular abnormalities), as seen during the adult period when the GK\/Par rats are overtly diabetic, represents an acquired defect (perhaps glucotoxicity). In terms of beta-cell population, the earliest alteration so far detected in the GK\/Par rat targets the size of the beta-cell population. Several convergent data suggest that the permanently reduced beta-cell mass in the GK\/Par rat reflects a limitation of beta-cell neogenesis during early fetal life, and it is conceivable that some genes among the set involved in GK diabetes belong to the subset of genes controlling early beta-cell development.<\/jats:p>","DOI":"10.2337\/diabetes.50.2007.s89","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:04:22Z","timestamp":1173207862000},"page":"S89","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":75,"title":["beta-cell function and viability in the spontaneously diabetic GK rat: information from the GK\/Par colony."],"prefix":"10.2337","volume":"50","author":[{"given":"B","family":"Portha","sequence":"first","affiliation":[{"name":"Laboratoire de Physiopathologie de la Nutrition, CNRS ESA 7059, Universit\u00e9 D. Diderot, Paris, France. portha@paris7.jussieu.fr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M H","family":"Giroix","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiopathologie de la Nutrition, CNRS ESA 7059, Universit\u00e9 D. Diderot, Paris, France. portha@paris7.jussieu.fr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Serradas","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiopathologie de la Nutrition, CNRS ESA 7059, Universit\u00e9 D. Diderot, Paris, France. portha@paris7.jussieu.fr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M N","family":"Gangnerau","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiopathologie de la Nutrition, CNRS ESA 7059, Universit\u00e9 D. Diderot, Paris, France. portha@paris7.jussieu.fr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Movassat","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiopathologie de la Nutrition, CNRS ESA 7059, Universit\u00e9 D. Diderot, Paris, France. portha@paris7.jussieu.fr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Rajas","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiopathologie de la Nutrition, CNRS ESA 7059, Universit\u00e9 D. Diderot, Paris, France. portha@paris7.jussieu.fr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Bailbe","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiopathologie de la Nutrition, CNRS ESA 7059, Universit\u00e9 D. Diderot, Paris, France. portha@paris7.jussieu.fr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Plachot","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiopathologie de la Nutrition, CNRS ESA 7059, Universit\u00e9 D. Diderot, Paris, France. portha@paris7.jussieu.fr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Mithieux","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiopathologie de la Nutrition, CNRS ESA 7059, Universit\u00e9 D. Diderot, Paris, France. portha@paris7.jussieu.fr"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J C","family":"Marie","sequence":"additional","affiliation":[{"name":"Laboratoire de Physiopathologie de la Nutrition, CNRS ESA 7059, Universit\u00e9 D. Diderot, Paris, France. portha@paris7.jussieu.fr"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/50\/suppl_1\/S89\/533177\/s89.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/50\/suppl_1\/S89\/533177\/s89.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:09:47Z","timestamp":1667405387000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/50\/suppl_1\/S89\/11683\/beta-cell-function-and-viability-in-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2,1]]},"references-count":0,"journal-issue":{"issue":"suppl_1","published-print":{"date-parts":[[2001,2,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diabetes.50.2007.s89","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,2,1]]}}}