{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T08:58:50Z","timestamp":1790326730672,"version":"4.1.0"},"reference-count":55,"publisher":"American Diabetes Association","issue":"5","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,5,1]]},"abstract":"<jats:p>Coronary microcirculation dysfunction may be associated with myocardial perfusion defects on thallium imaging in diabetic patients without coronary artery stenosis. Microvascular coronary adaptation to increased myocardial oxygen demand in response to sympathetic stimulation evoked by the cold pressor test was examined in 22 type 2 diabetic patients with thallium imaging defects and in 15 control subjects. Both the diabetic patients and control subjects had angiographically normal coronary arteries and no other risk factors. Despite a similar increase in the rate-pressure product in the two groups (22.6 \u00b1 12.4% in diabetic patients and 31.8 \u00b1 8.2% in control subjects, NS), coronary blood flow increase in the left anterior descending artery (mean flow velocity measured by intracoronary Doppler multiplied by the cross-sectional area measured by digital angiography) was significantly lower in diabetic patients than in control subjects (14.7 \u00b1 19.8 vs. 75.5 \u00b1 13.5%, respectively; P = 0.0001). In addition, when there was a positive correlation between the two parameters in control subjects (r = 0.651, P &amp;lt; 0.01), there was no relationship in diabetic patients (r = 0.054). In conclusion, vasodilation of the coronary microcirculation in response to sympathetic stimulation evoked by the cold pressor test is impaired in type 2 diabetic patients without epicardial artery lesions. This microvascular impairment during sympathetic stimulation may explain exercise-induced myocardial perfusion abnormalities observed in these patients and may impair microcirculatory coronary vasodilation during current life stress episodes such as exercise, mental stress, or cold exposition.<\/jats:p>","DOI":"10.2337\/diabetes.50.5.1180","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:04:22Z","timestamp":1173207862000},"page":"1180-1185","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":70,"title":["Impairment of Coronary Microvascular Dilation in Response to Cold Pressor\u2013Induced Sympathetic Stimulation in Type 2 Diabetic Patients With Abnormal Stress Thallium Imaging"],"prefix":"10.2337","volume":"50","author":[{"given":"Alain","family":"Nitenberg","sequence":"first","affiliation":[{"name":"Department of Physiology and Functional Investigations, Louis Mourier Hospital, University Hospital Xavier-Bichat, Colombes"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Se\u0301verine","family":"Ledoux","sequence":"additional","affiliation":[{"name":"Department of Physiology and Functional Investigations, Louis Mourier Hospital, University Hospital Xavier-Bichat, Colombes"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Valensi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology-Diabetology-Nutrition, Jean Verdier Hospital, University Hospital of Bobigny, Bondy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Re\u0301gis","family":"Sachs","sequence":"additional","affiliation":[{"name":"Department of Endocrinology-Diabetology-Nutrition, Jean Verdier Hospital, University Hospital of Bobigny, Bondy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Raymond","family":"Attali","sequence":"additional","affiliation":[{"name":"Department of Endocrinology-Diabetology-Nutrition, Jean Verdier Hospital, University Hospital of Bobigny, Bondy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Antony","sequence":"additional","affiliation":[{"name":"Department of Physiology and Functional Investigations, Louis Mourier Hospital, University Hospital Xavier-Bichat, Colombes"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031207181995400_R1","doi-asserted-by":"crossref","unstructured":"Nitenberg A, Valensi P, Sachs R, Dali M, Aptecar E, Attali JR: Impairment of coronary vascular reserve and Ach-induced coronary vasodilation in diabetic patients with angiographically normal coronary arteries and normal left ventricular systolic function. 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