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The results support the conclusion that E23K predisposes to type 2 diabetes by changing the channel\u2019s response to physiological variation of cytosolic nucleotides, resulting in KATP overactivity and discrete inhibition of insulin release.<\/jats:p>","DOI":"10.2337\/diabetes.51.2007.s363","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:04:22Z","timestamp":1173207862000},"page":"S363-S367","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":48,"title":["The Common Single Nucleotide Polymorphism E23K in KIR6.2 Sensitizes Pancreatic \u03b2-Cell ATP-Sensitive Potassium Channels Toward Activation Through Nucleoside Diphosphates"],"prefix":"10.2337","volume":"51","author":[{"given":"Christina","family":"Schwanstecher","sequence":"first","affiliation":[{"name":"From the Institute of Pharmacology and Toxicology, University of Braunschweig, Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Neugebauer","sequence":"additional","affiliation":[{"name":"From the Institute of Pharmacology and Toxicology, University of Braunschweig, Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Schulz","sequence":"additional","affiliation":[{"name":"From the Institute of Pharmacology and Toxicology, University of Braunschweig, Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"Schwanstecher","sequence":"additional","affiliation":[{"name":"From the Institute of Pharmacology and Toxicology, University of Braunschweig, Braunschweig, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031208000198600_R1","doi-asserted-by":"crossref","unstructured":"Polonsky KS, Sturis J, Bell GI: Non-insulin-dependent diabetes mellitus: a genetically programmed failure of the beta cell to compensate for insulin resistance. 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