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Islet pO2 was measured by impaling superficially located islets with a miniaturized Clark electrode. The pO2 measurements revealed slow (0.21 \u00b1 0.03 min\u22121) with superimposed rapid (3.1 \u00b1 0.3 min\u22121) oscillations. The average pO2 was 39 \u00b1 5 mmHg. Simultaneous recordings of pO2 in the exocrine pancreas were significantly lower (16 \u00b1 6 mmHg), but showed a slow and a rapid oscillatory activity with similar frequencies as seen in the endocrine pancreas. Corresponding measurements of portal insulin concentrations revealed insulin oscillations at a frequency of 0.22 \u00b1 0.02 min\u22121. The results are the first in vivo recordings of an oscillatory islet parameter with a frequency corresponding to that of plasma insulin oscillations; they support a primary role of metabolic oscillations in the induction of plasma insulin oscillations.<\/jats:p>","DOI":"10.2337\/diabetes.51.3.699","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T14:04:22Z","timestamp":1173189862000},"page":"699-703","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":34,"title":["Primary In Vivo Oscillations of Metabolism in the Pancreas"],"prefix":"10.2337","volume":"51","author":[{"given":"Peter","family":"Bergsten","sequence":"first","affiliation":[{"name":"Department of Medical Cell, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Westerlund","sequence":"additional","affiliation":[{"name":"Department of Medical Cell, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Liss","sequence":"additional","affiliation":[{"name":"Department of Medical Cell, Uppsala University, Uppsala, Sweden"},{"name":"Department of Diagnostic Radiology, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per-Ola","family":"Carlsson","sequence":"additional","affiliation":[{"name":"Department of Medical Cell, Uppsala University, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031223311113200_R1","doi-asserted-by":"crossref","unstructured":"Goodner CJ, Walike BC, Koerker DJ, Ensinck JW, Brown AC, Chideckel EW, Palmer J, Kalnasy L: Insulin, glucagon, and glucose exhibit synchronous, sustained oscillations in fasting monkeys. 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