{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:44:24Z","timestamp":1790873064258,"version":"4.1.0"},"reference-count":11,"publisher":"American Diabetes Association","issue":"3","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,3,1]]},"abstract":"<jats:p>The hormone resistin has been suggested to link obesity to type 2 diabetes by modulating steps in the insulin-signaling pathway and inducing insulin resistance. Thus, the resistin gene represents a potential candidate for the etiology of insulin resistance and type 2 diabetes. In this study, we analyzed the coding sequence of the three exons of the resistin gene, together with its 5\u2032 regulatory region and 3\u2032 untranslated region (UTR), by single-strand conformation polymorphism (SSCP) in 58 type 2 diabetic subjects, 59 obese subjects, and 60 normal subjects. Only one sequence variant was detected in the resistin gene. Sequencing of this variant revealed the presence of a single nucleotide substitution (SNP) in the 3\u2032-UTR of exon 3 (G1326C). Because 3\u2032-UTR SNPs have been shown to affect gene expression, we examined the frequency of this SNP in 591 subjects (198 obese subjects, 207 diabetic subjects, and 186 control subjects) by PCR amplification and BseRI digestion. No significant association was found between the G1326C variant and diabetes and obesity. Comparison of clinical and metabolic parameters between G1326C carriers and noncarriers again showed no significant difference. In conclusion, our data suggest that genetic defects of the resistin gene are unlikely to play a role in the etiology of these common disorders in our population.<\/jats:p>","DOI":"10.2337\/diabetes.51.3.860","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:04:22Z","timestamp":1173207862000},"page":"860-862","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":88,"title":["Human <i>Resistin<\/i> Gene, Obesity, and Type 2 Diabetes"],"prefix":"10.2337","volume":"51","author":[{"given":"Federica","family":"Sentinelli","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Division of Endocrinology, University of Rome \u201cLa Sapienza,\u201d Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Romeo","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Division of Endocrinology, University of Rome \u201cLa Sapienza,\u201d Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Arca","sequence":"additional","affiliation":[{"name":"Institute of Terapia Medica Sistematica, University of Rome \u201cLa Sapienza,\u201d Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Filippi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Division of Endocrinology, University of Rome \u201cLa Sapienza,\u201d Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frida","family":"Leonetti","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Division of Endocrinology, University of Rome \u201cLa Sapienza,\u201d Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Banchieri","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Division of Endocrinology, University of Rome \u201cLa Sapienza,\u201d Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Di Mario","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Division of Endocrinology, University of Rome \u201cLa Sapienza,\u201d Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Giorgio","family":"Baroni","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Division of Endocrinology, University of Rome \u201cLa Sapienza,\u201d Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031222534480400_R1","doi-asserted-by":"crossref","unstructured":"Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA: The hormone resistin links obesity to diabetes. 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