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We found that resistin expression in 3T3-L1 adipocytes was significantly upregulated by high glucose concentrations and was suppressed by insulin. Dexamethasone increased expression of both resistin mRNA and protein 2.5- to 3.5-fold in 3T3-L1 adipocytes and by \u223c70% in white adipose tissue from mice. In contrast, treatment with troglitazone, a thiazolidinedione antihyperglycemic agent, or TNF-\u03b1 suppressed resistin expression by \u223c80%. Epinephrine and somatropin were both moderately inhibitory, reducing expression of both the transcript and the protein by 30\u201350% in 3T3-L1 adipocytes. Taken together, these data make it clear that resistin expression is regulated by a variety of hormones and that cytokines are related to glucose metabolism. Furthermore, they suggest that these factors affect insulin sensitivity and fat tissue mass in part by altering the expression and eventual secretion of resistin from adipose cells.<\/jats:p>","DOI":"10.2337\/diabetes.51.6.1737","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:04:22Z","timestamp":1173207862000},"page":"1737-1744","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":146,"title":["Humoral Regulation of Resistin Expression in 3T3-L1 and Mouse Adipose Cells"],"prefix":"10.2337","volume":"51","author":[{"given":"Nobuhiro","family":"Shojima","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Sakoda","sequence":"additional","affiliation":[{"name":"Institute for Adult Disease, Asahi Life Foundation, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehide","family":"Ogihara","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Midori","family":"Fujishiro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Katagiri","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Tohoku, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motonobu","family":"Anai","sequence":"additional","affiliation":[{"name":"Institute for Adult Disease, Asahi Life Foundation, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Onishi","sequence":"additional","affiliation":[{"name":"Institute for Adult Disease, Asahi Life Foundation, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiraku","family":"Ono","sequence":"additional","affiliation":[{"name":"Institute for Adult Disease, Asahi Life Foundation, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouichi","family":"Inukai","sequence":"additional","affiliation":[{"name":"Fourth Department of Internal Medicine, Saitama Medical School, Saitama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miho","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Institute for Adult Disease, Asahi Life Foundation, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitomo","family":"Oka","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Tohoku, Sendai, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoichiro","family":"Asano","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","reference":[{"key":"2022031209360309500_R1","doi-asserted-by":"crossref","unstructured":"Steppan CM, Bailey ST, Brown ER, Banerjee JB, Wright CM, Patel HR, Ahina RS, Lazar MA: The hormone resistin links obesity to diabetes. 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