{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:04:47Z","timestamp":1785521087507,"version":"3.56.0"},"reference-count":39,"publisher":"American Diabetes Association","issue":"6","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,6,1]]},"abstract":"<jats:p>Diabetes-prone (DP) BB rats spontaneously develop insulin-dependent diabetes resembling human type 1 diabetes. They also exhibit lifelong T-cell lymphopenia. Functional and genetic data support the hypothesis that the gene responsible for the lymphopenia, Lyp, is also a diabetes susceptibility gene, named Iddm1. We constructed a 550-kb P1-derived artificial chromosome contig of the region. Here, we present a corrected genetic map reducing the genetic interval to 0.2 cM and the physical interval to 150\u2013290 kb. A total of 13 genes and six GenomeScan models are assigned to the homologous human DNA segment on HSA7q36.1, 8 of which belong to the family of immune-associated nucleotides (Ian genes). Two of these are orthologous to mouse Ian1 and -4, both excellent candidates for Iddm1. In normal rats, they are expressed in the thymus and T-cell regions of the spleen. In the thymus of lymphopenic rats, Ian1 exhibits wild-type expression patterns, whereas Ian4 expression is reduced. Mutational screening of their coding sequences revealed a frameshift mutation in Ian4 among lymphopenic rats. The mutation results in a truncated protein in which the COOH-terminal 215 amino acids\u2014including the anchor localizing the protein to the outer mitochondrial membrane\u2014are replaced by 19 other amino acids. We propose that Ian4 is identical to Iddm1.<\/jats:p>","DOI":"10.2337\/diabetes.51.6.1972","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:04:22Z","timestamp":1173207862000},"page":"1972-1979","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":136,"title":["The Diabetes-Prone BB Rat Carries a Frameshift Mutation in<i>Ian4<\/i>, a Positional Candidate of<i>Iddm1<\/i>"],"prefix":"10.2337","volume":"51","author":[{"given":"Lars","family":"Hornum","sequence":"first","affiliation":[{"name":"Type I Pharmacology, Hagedorn Research Institute, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"R\u00f8mer","sequence":"additional","affiliation":[{"name":"Pharmacological Research 4, Novo Nordisk, Bagsv\u00e6rd, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle","family":"Markholst","sequence":"additional","affiliation":[{"name":"Type I Pharmacology, Hagedorn Research Institute, Gentofte, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031209380347300_R1","doi-asserted-by":"crossref","unstructured":"Crisa\u0301 L, Mordes JP, Rossini AA: Autoimmune diabetes mellitus in the BB rat. 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