{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T04:07:10Z","timestamp":1783570030031,"version":"3.55.0"},"reference-count":25,"publisher":"American Diabetes Association","issue":"7","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,7,1]]},"abstract":"<jats:p>Over the past 5 years, microarrays have greatly facilitated large-scale analysis of gene expression levels. Although these arrays were not specifically geared to represent tissues and pathways known to be affected by diabetes, they have been used in both type 1 and type 2 diabetes research. To prepare a tool that is particularly useful in the study of type 1 diabetes, we have assembled a nonredundant set of 3,400 clones representing genes expressed in the mouse pancreas or pathways known to be affected by diabetes. We have demonstrated the usefulness of this clone set by preparing a cDNA glass microarray, the PancChip, and using it to analyze pancreatic gene expression from embryonic day 14.5 through adulthood in mice. The clone set and corresponding array are useful resources for diabetes research.<\/jats:p>","DOI":"10.2337\/diabetes.51.7.1997","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:04:22Z","timestamp":1173207862000},"page":"1997-2004","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":65,"title":["Functional Genomics of the Endocrine Pancreas"],"prefix":"10.2337","volume":"51","author":[{"given":"L. Marie","family":"Scearce","sequence":"first","affiliation":[{"name":"Department of Genetics, University of Pennsylvania, Philadephia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Brestelli","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Pennsylvania, Philadephia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon K.","family":"McWeeney","sequence":"additional","affiliation":[{"name":"Center for Bioinformatics, University of Pennsylvania, Philadephia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Pennsylvania, Philadephia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Mazzarelli","sequence":"additional","affiliation":[{"name":"Center for Bioinformatics, University of Pennsylvania, Philadephia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah F.","family":"Pinney","sequence":"additional","affiliation":[{"name":"Center for Bioinformatics, University of Pennsylvania, Philadephia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Pizarro","sequence":"additional","affiliation":[{"name":"Center for Bioinformatics, University of Pennsylvania, Philadephia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Christian J.","family":"Stoeckert","sequence":"additional","affiliation":[{"name":"Center for Bioinformatics, University of Pennsylvania, Philadephia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra W.","family":"Clifton","sequence":"additional","affiliation":[{"name":"Genome Sequencing Center, Washington University, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Alan","family":"Permutt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Washington University, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Harvard University, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"Melton","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Harvard University, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus H.","family":"Kaestner","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Pennsylvania, Philadephia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031222565396200_R1","doi-asserted-by":"crossref","unstructured":"Cardozo AK, Heimberg H, Heremans Y, Leeman R, Kutlu B, Kruhoffer M, Orntoft T, Eizirik DL: A Comprehensive analysis of cytokine-induced and nuclear Factor-kappa B-dependent genes in primary rat pancreatic beta-cells. J Biol Chem\u2008276:48879\u201348886, 2001","DOI":"10.1074\/jbc.M108658200"},{"key":"2022031222565396200_R2","doi-asserted-by":"crossref","unstructured":"Zimmer Y, Milo-Landesman D, Svetlanov A, Efrat S: Genes induced by growth arrest in a pancreatic b cell line: identification by analysis of cDNA arrays. FEBS Lett\u2008457:65\u201370, 1999","DOI":"10.1016\/S0014-5793(99)01008-X"},{"key":"2022031222565396200_R3","doi-asserted-by":"crossref","unstructured":"Joussen AM, Huang S: Mo\u0308glichkeiten einer breitspektrumanalyse von genexpressionmustern mittels cDNA-arrays: gene expression profiling using cDNA microarrays. Der Opthalmologe\u200898:568\u2013573, 2001","DOI":"10.1007\/s003470170121"},{"key":"2022031222565396200_R4","doi-asserted-by":"crossref","unstructured":"Boel E, Albrektsen T, Fleckner J, Selmer J: Modulation of metabolism through transcriptional control has created new treatment opportunities for type 2 diabetes. Curr Pharm Biotechnol\u20081:63\u201371, 2000","DOI":"10.2174\/1389201003379004"},{"key":"2022031222565396200_R5","doi-asserted-by":"crossref","unstructured":"Tobe K, Suzuki R, Aoyama M, Yamauchi T, Kamon J, Kubota N, Terauchi Y, Matsui J, Akanuma Y, Kimura S, Tanaka J, Abe M, Ohsumi J, Nagai R, Kadowaki T: Increased expression of the sterol regulatory element-binding protein-1 gene in insulin receptor substrate-2-\/- mouse liver. J Biol Chem\u2008276:38337\u201338340, 2001","DOI":"10.1074\/jbc.C100160200"},{"key":"2022031222565396200_R6","doi-asserted-by":"crossref","unstructured":"Aitman T, Glazier A, Wallace C, Cooper L, Norsworthy P, Wahid F, Al-Majali K, Trembling P, Mann C, Shoulders C, Graf D, St Lezin E, Kurtz T, Kren V, Pravenec M, Ibrahimi A, Abumrad N, Stanton L, Scott J: Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat Genet\u200821:76\u201383, 1999","DOI":"10.1038\/5013"},{"key":"2022031222565396200_R7","doi-asserted-by":"crossref","unstructured":"Nadler ST, Stoehr JP, Schuler KL, Tanimoto G, Yandell BS, Attie AD: The expression of adipogenic genes is decreased in obesity and diabetes mellitus. Proc Natl Acad Sci U S A\u200897:11371\u201311376, 2000","DOI":"10.1073\/pnas.97.21.11371"},{"key":"2022031222565396200_R8","doi-asserted-by":"crossref","unstructured":"Nadler ST, Attie AD: Please pass the chips: genomic insights into obesity and diabetes. J Nutr\u2008131:2078\u20132081, 2001","DOI":"10.1093\/jn\/131.8.2078"},{"key":"2022031222565396200_R9","doi-asserted-by":"crossref","unstructured":"Hegde P, Qi R, Abernathy K, Cheryl G, Dharap S, Gaspard R, Earle-Hughes J, Snesrud E, Lee N, Quakenbush J: A concise guide to cDNA microarray analysis. Biotechniques\u200829:548\u2013550, 2000","DOI":"10.2144\/00293bi01"},{"key":"2022031222565396200_R10","doi-asserted-by":"crossref","unstructured":"Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem\u2008162:156\u2013159, 1987","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"2022031222565396200_R11","unstructured":"Dudoit S, Yang YH, Callow MJ, Speed TP: Statistical methods for identifying differentially expressed genes in replicated cDNA microarray experiments [article online]. Available from http:\/\/www.stat.berkeley.edu\/tech-reports\/index.html. Accessed September 2000"},{"key":"2022031222565396200_R12","doi-asserted-by":"crossref","unstructured":"Yang YH, Dudoit S, Luu P, Speed T: Normalization of cDNA microarray data. Proceedings of SPIE, Microarrays: Optical Technologies and Informatics Bittner ML, Chen Y, Dorsel AN, Dougherty ER, Eds.\u20084266:141\u2013152, 2001","DOI":"10.1117\/12.427982"},{"key":"2022031222565396200_R13","doi-asserted-by":"crossref","unstructured":"Permutt M, Koranyi L, Keller K, Lacy P, Scharp D, Mueckler M: Cloning and functional expression of a human pancreatic islet glucose-transporter cDNA. Proc Natl Acad Sci U S A\u200886:8688\u20138692, 1989","DOI":"10.1073\/pnas.86.22.8688"},{"key":"2022031222565396200_R14","doi-asserted-by":"crossref","unstructured":"Takeda J, Yano H, Eng S, Zeng Y, Bell G: A molecular inventory of human pancreatic islets: sequence analysis of 1000 cDNA clones. Hum Mol Genet\u20082:1793\u20131798, 1993","DOI":"10.1093\/hmg\/2.11.1793"},{"key":"2022031222565396200_R15","doi-asserted-by":"crossref","unstructured":"Ferrer J, Wasson J, Schoor K, Mueckler M, Donis-Keller H, Permutt M: Mapping novel pancreatic islet genes to human chromosomes. Diabetes\u200846:386\u2013392, 1997","DOI":"10.2337\/diabetes.46.3.386"},{"key":"2022031222565396200_R16","doi-asserted-by":"crossref","unstructured":"Davidson SB, Crabtree J, Brunk BP, Schug J, Tannen V, Overton GC, C. J. Stoeckert J: K2\/Kleisli and GUS: experiments in integrated access to genomic data sources. IBM Systems Journal\u200840:512\u2013531, 2001","DOI":"10.1147\/sj.402.0512"},{"key":"2022031222565396200_R17","doi-asserted-by":"crossref","unstructured":"Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, Harris MA, Hill DP, Issel-Tarver L, Kasarskis A, Lewis S, Matese JC, Richardson JE, Ringwald M, Rubin GM, Sherlock G: Gene ontology: tool for the unification of biology. Nat Genet\u200825:25, 2000","DOI":"10.1038\/75556"},{"key":"2022031222565396200_R18","unstructured":"Ashburner M, Ball CA, Blake JA, Butler H, Cherry JM, Corradi J, Dolinski K, Eppig JT, Harris M, Hill DP, Lewis S, Marshall B, Mungall C, Reiser L, Rhee S, Richardson JE, Richter J, Ringwald M, Rubin GM, Sherlock G, Yoon J: Creating the gene ontology resource: design and implementation. Genome Res\u200811:1425\u20131433, 2001"},{"key":"2022031222565396200_R19","doi-asserted-by":"crossref","unstructured":"Warrington J, Nair A, Mahadevappa M, Tsyganskaya M: Comparison of human adult and fetal expression and identification of 535 housekeeping\/maintenance genes. Physiol Genomics\u20082:143\u2013147, 2000","DOI":"10.1152\/physiolgenomics.2000.2.3.143"},{"key":"2022031222565396200_R20","doi-asserted-by":"crossref","unstructured":"Stears RL, Getts RC, Gullans SR: A novel, sensitive detection system for high-density microarrays using dendrimer technology. Physiol Genomics\u20083:93\u201399, 2000","DOI":"10.1152\/physiolgenomics.2000.3.2.93"},{"key":"2022031222565396200_R21","doi-asserted-by":"crossref","unstructured":"Fellenberg K, Hauser NC, Brors B, Neutzner A, Hoheisel JD, Vingron M: Correspondence analysis applied to microarray data. Proc Natl Acad Sci U S A\u200898:10781\u201310786, 2001","DOI":"10.1073\/pnas.181597298"},{"key":"2022031222565396200_R22","doi-asserted-by":"crossref","unstructured":"Tomasetto C, Rio M, Gautier C, Wolf C, Hareuveni M, Chambon P, Lathe R: hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma. EMBO J\u20089:407\u2013414, 1990","DOI":"10.1002\/j.1460-2075.1990.tb08125.x"},{"key":"2022031222565396200_R23","doi-asserted-by":"crossref","unstructured":"Lefe\u0300bvre O, Wolf C, Kedinger M, Chenard M, Tomasetto C, Chambon P, Rio MC: The mouse one P-domain (pS2) and two domain (mSP) genes exhibit distinct patterns of expression. J Cell Biol\u2008122:191\u2013198, 1993","DOI":"10.1083\/jcb.122.1.191"},{"key":"2022031222565396200_R24","doi-asserted-by":"crossref","unstructured":"Ribieras S, Lefe\u0300bvre O, Tomasetto C, Rio MC: Mouse trefoil factor genes: genomic organization, sequences and methylation analyses. Gene\u2008266:67\u201375, 2001","DOI":"10.1016\/S0378-1119(01)00380-8"},{"key":"2022031222565396200_R25","doi-asserted-by":"crossref","unstructured":"Schug J, Diskins S, Mazzarelli J, Bunk BP, Stoeckert CJ: Predicting gene ontology functions from ProDom and CDD protein domains. Genome Res\u200812.","DOI":"10.1101\/gr.222902"}],"container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/51\/7\/1997\/340927\/db0702001997.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/51\/7\/1997\/340927\/db0702001997.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:14:45Z","timestamp":1667405685000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/51\/7\/1997\/34539\/Functional-Genomics-of-the-Endocrine-PancreasThe"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7,1]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2002,7,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diabetes.51.7.1997","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,7,1]]}}}