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Moreover, OXA release is stimulated by low glucose (2.8 mmol\/l), similar to glucagon secretion, and inhibited by high glucose (16.7 mmol\/l). Fasting increases plasma OXA, supporting the idea that orexin is released in response to hypoglycemia. Cells that secrete glucagon and insulin contain OXA and both cell types express orexin receptors. OXA increases glucagon secretion and decreases glucose-stimulated insulin release from isolated islets. OXA infusion increases plasma glucagon and glucose levels and decreases plasma insulin in fasted rats. We conclude that orexin-containing islet cells, like those in the brain and gut, are glucosensitive and part of a network of glucose \u201csensing\u201d cells that becomes activated when blood glucose levels fall. OXA may modulate islet hormone secretion to maintain blood glucose levels during fasting.<\/jats:p>","DOI":"10.2337\/diabetes.52.1.111","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:04:22Z","timestamp":1173207862000},"page":"111-117","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":101,"title":["Glucose Regulates the Release of Orexin-A From the Endocrine Pancreas"],"prefix":"10.2337","volume":"52","author":[{"given":"Raogo","family":"Ouedraogo","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Na\u0308slund","sequence":"additional","affiliation":[{"name":"Division of Surgery, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annette L.","family":"Kirchgessner","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology, State University of New York, Downstate Medical Center, Brooklyn, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031207592986700_R1","doi-asserted-by":"crossref","unstructured":"de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett FS 2nd, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG: The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. 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