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In the first experiment, we identified that long-term maintenance on a meal-feeding schedule attenuated rats\u2019 sensitivity to central administration of the melanocortin agonist MTII. The results from a second experiment demonstrate that the attenuation of the MTII-induced anorexia was due to learned schedules of food intake rather than food deprivation per se. Results from the final experiment suggest that this attenuation of MTII-induced anorexia may be independent of the decreased sensitivity caused by a high-fat diet. These results support the hypothesis that meal-feeding schedules can lead to anticipatory physiological responses that attenuate the anorexic effects of exogenous melanocortin agonists.<\/jats:p>","DOI":"10.2337\/diabetes.52.11.2684","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:04:22Z","timestamp":1173207862000},"page":"2684-2688","update-policy":"http:\/\/dx.doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":24,"title":["Learned Meal Initiation Attenuates the Anorexic Effects of the Melanocortin Agonist MTII"],"prefix":"10.2337","volume":"52","author":[{"given":"Stephen C.","family":"Benoit","sequence":"first","affiliation":[{"name":"From the Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah J.","family":"Clegg","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason G.","family":"Barrera","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randy J.","family":"Seeley","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen C.","family":"Woods","sequence":"additional","affiliation":[{"name":"From the Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","reference":[{"key":"2022031207444035400_R1","doi-asserted-by":"crossref","unstructured":"Woods SC, Seeley RJ: Adiposity signals and the control of energy homeostasis. 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