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Here we report that the G\/G genotype of a single nucleotide polymorphism (SNP) in the promoter of the human resistin gene, \u2212180C&amp;gt;G, had significantly increased basal promoter activity in adipocytes. These data were recapitulated in vivo, where G\/G homozygotes had significantly higher resistin mRNA levels in human abdominal subcutaneous fat. A significant interaction was also found between the \u2212180C&amp;gt;G SNP, a marker of oxidative stress (NAD[P]H quinone oxidoreductase mRNA) and homeostasis model assessment of insulin resistance. In addition, resistin mRNA was positively and independently correlated with insulin resistance and hepatic fat as measured by liver X-ray attenuation. These data implicate resistin in the pathophysiology of the human insulin resistance syndrome, an effect mediated by the \u2212180C&amp;gt;G promoter SNP and potentially cellular oxidative stress.<\/jats:p>","DOI":"10.2337\/diabetes.52.7.1611","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:04:22Z","timestamp":1173207862000},"page":"1611-1618","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":138,"title":["A Promoter Genotype and Oxidative Stress Potentially Link Resistin to Human Insulin Resistance"],"prefix":"10.2337","volume":"52","author":[{"given":"Steve R.","family":"Smith","sequence":"first","affiliation":[{"name":"Pennington Biomedical Research Center, Baton Rouge, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulu","family":"Bai","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center, Baton Rouge, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Charbonneau","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center, Baton Rouge, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenka","family":"Janderova\u0301","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center, Baton Rouge, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Argyropoulos","sequence":"additional","affiliation":[{"name":"Pennington Biomedical Research Center, Baton Rouge, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031209333536700_R1","doi-asserted-by":"crossref","unstructured":"Holcomb IN, Kabakoff RC, Chan B, Baker TW, Gurney A, Henzel W, Nelson C, Lowman HB, Wright BD, Skelton NJ, Frantz GD, Tumas DB, Peale FV Jr, Shelton DL, Hebert CC: FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family. 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