{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:32:42Z","timestamp":1790361162949,"version":"4.1.0"},"reference-count":50,"publisher":"American Diabetes Association","issue":"8","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2003,8,1]]},"abstract":"<jats:p>Abnormalities of dendritic cells (DCs) have been identified in type 1 diabetic patients and in nonobese diabetic (NOD) mice that are associated with augmented nuclear transcription factor (NF)-\u03baB activity. An imbalance that favors development of the immunogenic DCs may predispose to the disease, and restoration of the balance by administration of DCs deficient in NF-\u03baB activity may prevent diabetes. DCs propagated from NOD mouse bone marrow and treated with NF-\u03baB\u2013specific oligodeoxyribonucleotide (ODN) in vitro (NF-\u03baB ODN DC) were assessed for efficacy in prevention of diabetes development in vivo. Gel shift assay with DC nuclear extracts confirmed specific inhibition of NF-\u03baB DNA binding by NF-\u03baB ODN. The costimulatory molecule expression, interleukin (IL)-12 production, and immunostimulatory capacity in presenting allo- and islet-associated antigens by NF-\u03baB ODN DC were significantly suppressed. NF-\u03baB ODN renders DCs resistant to lipopolysaccharide stimulation. Administration of 2 \u00d7 106 NF-\u03baB ODN DCs into NOD mice aged 6\u20137 weeks effectively prevented the onset of diabetes. T-cells from pancreatic lymph nodes of NF-\u03baB ODN DC\u2013treated animals exhibited hyporesponsiveness to islet antigens with low production of interferon-\u03b3 and IL-2. These findings provide novel insights into the mechanisms of autoimmune diabetes and may lead to development of novel preventive strategies.<\/jats:p>","DOI":"10.2337\/diabetes.52.8.1976","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:04:22Z","timestamp":1173207862000},"page":"1976-1985","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":66,"title":["Prevention of Diabetes in NOD Mice by Administration of Dendritic Cells Deficient in Nuclear Transcription Factor-\u03baB Activity"],"prefix":"10.2337","volume":"52","author":[{"given":"Linlin","family":"Ma","sequence":"first","affiliation":[{"name":"Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiguang","family":"Qian","sequence":"additional","affiliation":[{"name":"Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Liang","sequence":"additional","affiliation":[{"name":"Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianfu","family":"Wang","sequence":"additional","affiliation":[{"name":"Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer E.","family":"Woodward","sequence":"additional","affiliation":[{"name":"Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick","family":"Giannoukakis","sequence":"additional","affiliation":[{"name":"Diabetes Institute, Department of Pathology, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul D.","family":"Robbins","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics and Biochemistry, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Bertera","sequence":"additional","affiliation":[{"name":"Division of Immunogenetics, Children\u2019s Hospital of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Trucco","sequence":"additional","affiliation":[{"name":"Division of Immunogenetics, Children\u2019s Hospital of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Fung","sequence":"additional","affiliation":[{"name":"Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Lu","sequence":"additional","affiliation":[{"name":"Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031209053115900_R1","doi-asserted-by":"crossref","unstructured":"Bach JF: Insulin-dependent diabetes mellitus as an autoimmune disease. Endocr Rev\u200815:516\u2013542,1994","DOI":"10.1210\/edrv-15-4-516"},{"key":"2022031209053115900_R2","doi-asserted-by":"crossref","unstructured":"Ludewig B, Odermatt B, Ochsenbein AF, Zinkernagel RM, Hengartner H: Role of dendritic cells in the induction and maintenance of autoimmune diseases. Immunol Rev\u2008169:45\u201354,1999","DOI":"10.1111\/j.1600-065X.1999.tb01305.x"},{"key":"2022031209053115900_R3","doi-asserted-by":"crossref","unstructured":"Lechler R, Ng WF, Steinman RM: Dendritic cell in transplantation: friend or foe?Immunity\u200814:357\u2013368,2001","DOI":"10.1016\/S1074-7613(01)00116-9"},{"key":"2022031209053115900_R4","doi-asserted-by":"crossref","unstructured":"Banchereau J, Briere F, Caux C, Davoust S, Lebecque S, Liu JY, PulendranB, Palika K: Immunobiology of dendritic cells. Annu Rev Immunol\u200818:767\u2013811,2000","DOI":"10.1146\/annurev.immunol.18.1.767"},{"key":"2022031209053115900_R5","doi-asserted-by":"crossref","unstructured":"Lu L, Mccaslin D, Starzl TE, Thomson AW: Bone marrow-derived dendritic cell progenitors (NLDC 145+, MHC classII+, B7-1dim, B7-2\u2212) induce alloantigen-specific hyporesponsiveness in murine T lymphocytes. Transplantation\u200860:1539\u20131545,1995","DOI":"10.1097\/00007890-199560120-00028"},{"key":"2022031209053115900_R6","doi-asserted-by":"crossref","unstructured":"Roncarolo M-G, Levings MK, Traversari C: Differentiation of T regulatory cells by immature dendritic cells (Review). J Exp Med\u2008193:F5\u2013F9,2001","DOI":"10.1084\/jem.193.2.F5"},{"key":"2022031209053115900_R7","doi-asserted-by":"crossref","unstructured":"Takahashi K, Honeyman MC, Harrison LC: Impaired yield, phenotype, and function of monocyte-derived dendritic cells in humans at risk for insulin-dependent diabetes. J Immunol\u2008161:2629\u20132635,1998","DOI":"10.4049\/jimmunol.161.5.2629"},{"key":"2022031209053115900_R8","doi-asserted-by":"crossref","unstructured":"Jansen A, van Hagen M, Drexhage HA: Defective maturation and function of antigen-presenting cells in type I diabetes. Lancer\u2008345:491\u2013492,1995","DOI":"10.1016\/S0140-6736(95)90586-3"},{"key":"2022031209053115900_R9","doi-asserted-by":"crossref","unstructured":"Serreze DV, Gaskins HR, Leiter EH: Defects in the differentiation and function of APCs in NOD\/Lt mice. J Immunol\u2008150:2534\u20132543, 1993","DOI":"10.4049\/jimmunol.150.6.2534"},{"key":"2022031209053115900_R10","doi-asserted-by":"crossref","unstructured":"Green EA, Flavell RA: Tumor necrosis factors and the progression of diabetes in non-obese diabetic mice. Immunol Rev\u2008167:11\u201322,1999","DOI":"10.1111\/j.1600-065X.1999.tb01302.x"},{"key":"2022031209053115900_R11","doi-asserted-by":"crossref","unstructured":"Rescigno M, Martino M, Sutherland CL, Gold MR, Ricciardi-Castagnoli P: Dendritic cell survival and maturation are regulated by different signaling pathways. J Exp Med\u2008188:2175\u20132180,1998","DOI":"10.1084\/jem.188.11.2175"},{"key":"2022031209053115900_R12","doi-asserted-by":"crossref","unstructured":"Weih F, Carrasco D, Durham SK, Barton DS, Rizzo CA, Ryseck RP, Lira SA, Bravo R: Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-\u03baB\/Rel family. Cell\u200880:331\u2013340,1995","DOI":"10.1016\/0092-8674(95)90416-6"},{"key":"2022031209053115900_R13","doi-asserted-by":"crossref","unstructured":"Wu L, D\u2019Amico A, Winkel K, Suter M, Lo, Shortman K: RelB is essential for the development of myeloid-related CD8\u03b1+ dendritic cells but not of lymphoid-related CD8\u03b1+ dendritic cells. Immunity\u20089:839\u2013847,1998","DOI":"10.1016\/S1074-7613(00)80649-4"},{"key":"2022031209053115900_R14","doi-asserted-by":"crossref","unstructured":"Thanos D, Maniatis T: NF-\u03baB: a lesson in family values. Cell\u200880:592\u2013532,1995","DOI":"10.1016\/0092-8674(95)90506-5"},{"key":"2022031209053115900_R15","doi-asserted-by":"crossref","unstructured":"May MJ, Ghosh S: Signal transduction through NF-\u03baB. Immunol Today\u200819:80\u201388,1998","DOI":"10.1016\/S0167-5699(97)01197-3"},{"key":"2022031209053115900_R16","doi-asserted-by":"crossref","unstructured":"Weaver DJ Jr, Poligone B, Bui T, Abdel-Motal UM, Baldwin AS Jr, Tisch R: Dendritic cells from nonobese diabetic mice exhibit a defect in NF-\u03baB regulation due to a hyperactive I\u03baB kinase. J Immunol\u2008167:1461\u20131468,2001","DOI":"10.4049\/jimmunol.167.3.1461"},{"key":"2022031209053115900_R17","doi-asserted-by":"crossref","unstructured":"Poligone B, Weaver DJ Jr, Sen P, Baldwin AS Jr, Tisch R: Elevated NF-\u03baB activation in nonobese diabetic mouse dendritic cells results in enhanced APC function. J Immunol\u2008168:188\u2013196,2002","DOI":"10.4049\/jimmunol.168.1.188"},{"key":"2022031209053115900_R18","doi-asserted-by":"crossref","unstructured":"Steptoe RJ, Ritchie JM, Harrison LC: Increased generation of dendritic cells from myeloid progenitors in autoimmune-prone nonobese diabetic mice. J Immunol\u2008168:5032\u20135041,2002","DOI":"10.4049\/jimmunol.168.10.5032"},{"key":"2022031209053115900_R19","doi-asserted-by":"crossref","unstructured":"Giannoukakis N, Bonham CA, Qian, Chen Z, Peng L, Harnaha J, Li W, Thomson AW, Fung JJ, Robbins PD, Lu L: Prolongation of cardiac allograft survival using dendritic cells treated with NF-\u03baB decoy oligodeoxyribonucleotides. Mol Ther\u20081:430\u2013437,2000","DOI":"10.1006\/mthe.2000.0060"},{"key":"2022031209053115900_R20","doi-asserted-by":"crossref","unstructured":"Gotoh M, Maki T, Kiyoizumi T, Satomi S, Monaco AP: An improved method for isolation of mouse pancreatic islets. Transplantation\u200840:437\u2013438,1985","DOI":"10.1097\/00007890-198510000-00018"},{"key":"2022031209053115900_R21","doi-asserted-by":"crossref","unstructured":"Alexander AM, Crawford M, Bertera S, Rudert WA, Takikawa O, Robbins PD, Trucco M: Indoleamine 2,3-dioxygenase expression in transplanted NOD islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes. Diabetes\u200851:356\u2013365. 2002","DOI":"10.2337\/diabetes.51.2.356"},{"key":"2022031209053115900_R22","doi-asserted-by":"crossref","unstructured":"Lu L, Qian S, Hershberger PA, Rudert WA, Li Y, Chambers FG, Lynch DH, Thomson AW: Fas ligand (CD95L) and B7 expression on dendritic cells provide counter-regulatory signals for T-cell survival and proliferation. J Immunol\u2008158:5676\u20135684,1997","DOI":"10.4049\/jimmunol.158.12.5676"},{"key":"2022031209053115900_R23","doi-asserted-by":"crossref","unstructured":"Kim KS, Kang Y, Choi SE, Kim JH, Kim HM, Sun B, Jun HS, Yoon JW: Modulation of glucocorticoid-induced GAD expression in pancreatic \u03b2-cells by transcriptional activation of the GAD67 promoter and its possible effect on the development of diabetes. Diabetes\u200851:2764\u20132772,2002","DOI":"10.2337\/diabetes.51.9.2764"},{"key":"2022031209053115900_R24","doi-asserted-by":"crossref","unstructured":"Lu L, Bonham CA, Liang X, Zhen Z, Li W, Wang L, Watkins S, Nalesnik MA, Schlissel MS, Demestris AJ, Fung JJ, Qian S: Liver-derived DEC205+ B220+ CD19\u2212 dendritic cells regulate T-cell response. J Immunol\u2008166:7042\u20137052,2001","DOI":"10.4049\/jimmunol.166.12.7042"},{"key":"2022031209053115900_R25","doi-asserted-by":"crossref","unstructured":"Lu L, Bonham CA, Chambers FG, Watkins SC, Hoffman RA, Simmons RL, Thomson AW: Induction of nitric oxide synthase in mouse dendritic cells by IFN-\u03b3, endotoxin, and interaction with allogeneic T-cells: nitric oxide production is associated with dendritic cell apoptosis. J Immunol\u2008157:3577\u20133586,1996","DOI":"10.4049\/jimmunol.157.8.3577"},{"key":"2022031209053115900_R26","doi-asserted-by":"crossref","unstructured":"Lu L, Li W, Zhong C, Qian S, Fung JJ, Thomson AW, Starzl TE: Increased apoptosis of immunoreactive host cells and augmented donor leukocyte chimerism, not sustained inhibition of B7 molecule expression are associated with prolonged cardiac allograft survival in mice preconditioned with immature donor dendritic cells plus anti-CD40L mAb. Transplantation\u200868:747\u2013757,1999","DOI":"10.1097\/00007890-199909270-00006"},{"key":"2022031209053115900_R27","doi-asserted-by":"crossref","unstructured":"Lu L, Thomson AW: Dendritic cells tolerogenicity and prospects for dendritic cell-based therapy of allograft rejection and autoimmune disease. In Dendritic Cells: Biology and Clinical Applications. 2nd ed. Lotze MT, Thomson AW, Eds. London, Academic Press,2001, p.587\u2013607","DOI":"10.1016\/B978-012455851-9\/50081-X"},{"key":"2022031209053115900_R28","doi-asserted-by":"crossref","unstructured":"Murphy TL, Cleveland MG, Kulesza P, Magram J, Murphy KM: Regulation of interleukin-12 p40 expression through an NF-\u03baB half-site. Mol Cell Bio\u20085:5258\u20135267,1995","DOI":"10.1128\/MCB.15.10.5258"},{"key":"2022031209053115900_R29","doi-asserted-by":"crossref","unstructured":"Xie QW, Kashiwabara Y, Nathan C: Role of transcription factor NF-\u03baB\/Rel in induction of nitric oxide synthase. J Biol Chem\u2008269:4705\u20134708,1994","DOI":"10.1016\/S0021-9258(17)37600-7"},{"key":"2022031209053115900_R30","doi-asserted-by":"crossref","unstructured":"Rissoan, M-C, Soumelis V, Kadowaki N, Grouard G, Briere F, de Waal Malefyt R, Liu Y-J: Reciprocal control of T helper cell and dendritic cell differentiation. Science\u2008283:1183\u20131186,1998","DOI":"10.1126\/science.283.5405.1183"},{"key":"2022031209053115900_R31","doi-asserted-by":"crossref","unstructured":"Feili-Hariri M, Dong X, Alber SM, Watkins SC, Salter RD, Morel PA: Immunotherapy of NOD mice with bone marrow\u2013derived dendritic cells. Diabetes\u200848:2300\u20132308,1999","DOI":"10.2337\/diabetes.48.12.2300"},{"key":"2022031209053115900_R32","doi-asserted-by":"crossref","unstructured":"Ridgway WM, Fasso J, Lanctot A, Garvey C, Fathman CG: Breaking self-tolerance in nonobese diabetic mice. J Exp Med\u2008183:1657\u20131662,1996","DOI":"10.1084\/jem.183.4.1657"},{"key":"2022031209053115900_R33","doi-asserted-by":"crossref","unstructured":"Trembleau 5, Penna G, Bosi B, Mortara A, Gately MK, Adorini L: Interleukin 12 administration induces T helper type 1 cells and accelerates autoimmune diabetes. J Exp Med\u2008181:817\u2013821,1995","DOI":"10.1084\/jem.181.2.817"},{"key":"2022031209053115900_R34","doi-asserted-by":"crossref","unstructured":"Healey D, Ozegbe P, Arden 8, Chandler P, Hutton J, Cooke A: In vivo activity and in vitro specificity of CD4+ Th1 and Th2 cells derived from the spleens of diabetic NOD mice. J Clin Invest\u200895:2979\u20132985,1995","DOI":"10.1172\/JCI118006"},{"key":"2022031209053115900_R35","doi-asserted-by":"crossref","unstructured":"Bach JF, Chatenoud L: Tolerance to islet autoantigens in type 1 diabetes. Ann Rev Immunol\u200819:131\u2013161,2001","DOI":"10.1146\/annurev.immunol.19.1.131"},{"key":"2022031209053115900_R36","doi-asserted-by":"crossref","unstructured":"Ludwig B, Odermatt B, Landmann S, Hengartner H, Zinkenagel: Dendritic cells induce autoimmune diabetes and maintain disease via de novo formation of local lymphoid tissue. J Exp Med\u2008188:1493\u20131501,1998","DOI":"10.1084\/jem.188.8.1493"},{"key":"2022031209053115900_R37","doi-asserted-by":"crossref","unstructured":"Fu F, Li Y, Qian S, Lu L, Chambers FD, Starzl TE, Fung JJ, Thomson AW: Costimulatory molecule-deficient dendritic cell progenitors (MHC class II+, B7-1dim, B7-2\u2212) prolong cardiac allograft survival in non-immunosuppressed recipients. Transplantation\u200862:659\u2013665,1996","DOI":"10.1097\/00007890-199609150-00021"},{"key":"2022031209053115900_R38","doi-asserted-by":"crossref","unstructured":"Lu L, Lee WC, Gambotto A, Zhong C, Robbin PD, Qian S, Fung JJ, Thomson AW: Transduction of dendritic cells with adenoviral vectors encoding CTLA4-lg markedly reduces their allostimulatory activity. Transplant Proc\u200831:797,1999","DOI":"10.1016\/S0041-1345(98)01774-6"},{"key":"2022031209053115900_R39","doi-asserted-by":"crossref","unstructured":"Lee WC, Zhong C, Qian S, Wan Y, Gauldie J, Mi Z, Robbins PD, Thomson AW, Lu L: Phenotype, function, and in vivo migration and survival of allogeneic dendritic cell progenitors genetically engineered to express TGF-\u03b2. Transplantation\u200866:1810\u20131817,1998","DOI":"10.1097\/00007890-199812270-00040"},{"key":"2022031209053115900_R40","doi-asserted-by":"crossref","unstructured":"Lee J, Burckart GJ: Nuclear factor kappa B: important transcription factor and therapeutic target. J Clin Pharmacol\u200838:981\u2013993,1998","DOI":"10.1177\/009127009803801101"},{"key":"2022031209053115900_R41","doi-asserted-by":"crossref","unstructured":"Chung Y-H, Jun H-S, Kang Y, Hirasawa K, Lee B-R, Rooijien NV, Yoon J-W: Role of macrophages and macrophage-derived cytokines in the pathogenesis of Kilham rat virus-induced autoimmune diabetes in diabetes-resistant BioBreeding rats. J Immunol\u2008159:466\u2013471,1997","DOI":"10.4049\/jimmunol.159.1.466"},{"key":"2022031209053115900_R42","doi-asserted-by":"crossref","unstructured":"Alleva DG, Pavlovich RP, Grant C, Kaser SB, Beller DI: Aberrant macrophage cytokine production is a conserved feature among autoimmune-prone mouse strains: elevated interleukin (IL)-12 and an imbalance in tumor necrosis factor-\u03b1 and IL-10 define a unique cytokine profile in macrophages from young nonobese diabetic mice. Diabetes\u200849:1106\u20131115,2000","DOI":"10.2337\/diabetes.49.7.1106"},{"key":"2022031209053115900_R43","doi-asserted-by":"crossref","unstructured":"Hayashi T, Morimoto M, Iwata H, Onodera T: Possible involvement of IL-12 in reovirus type-2-induced diabetes in newborn DBA\/1 mice. Scandinavian J Immunol\u200853:572\u2013578,2001","DOI":"10.1046\/j.1365-3083.2001.00907.x"},{"key":"2022031209053115900_R44","doi-asserted-by":"crossref","unstructured":"Haskins K, McDuitie M: Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T-cell clone. Science\u2008249:1433\u20131436,1990","DOI":"10.1126\/science.2205920"},{"key":"2022031209053115900_R45","doi-asserted-by":"crossref","unstructured":"Shevach EM: Regulatory T-cells in autoimmunity. Ann Rev Immunol\u200818:423\u2013449,2000","DOI":"10.1146\/annurev.immunol.18.1.423"},{"key":"2022031209053115900_R46","doi-asserted-by":"crossref","unstructured":"Takahashi T, Tagarni T, Yamazaki S, Uede I, Shimizu J, Sakaguchi N, Mak TW, Sakaguchi S: Immunologic self-tolerance maintained by CD25+ CD4+ regulatory T-cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med\u2008192:303\u2013310,2000","DOI":"10.1084\/jem.192.2.303"},{"key":"2022031209053115900_R47","doi-asserted-by":"crossref","unstructured":"Read S, Malmstroni V, Powrie F: Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+ CD4+ regulatory cells that control intestinal inflammation. J Exp Med\u2008192:295\u2013302,2000","DOI":"10.1084\/jem.192.2.295"},{"key":"2022031209053115900_R48","doi-asserted-by":"crossref","unstructured":"Groux H, O\u2019Garra A, Bigler M, Rouleau M, Antinenko S, de Vries JE, Roncarolo M-G: A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature\u2008389:737\u2013742,1997","DOI":"10.1038\/39614"},{"key":"2022031209053115900_R49","doi-asserted-by":"crossref","unstructured":"Roncarolo M-G, Levings MK: The role of different subsets of T regulatory cells in controlling autoimmunity. Curr Opin Immunol\u200812:676\u2013683,2000","DOI":"10.1016\/S0952-7915(00)00162-X"},{"key":"2022031209053115900_R50","doi-asserted-by":"crossref","unstructured":"Feili-Hariri M, Falkner DH, Morel PA: Regulatory Th2 response induced following adoptive transfer of dendritic cells in prediabetic NOD mice. European J Immunol\u200832:2021\u20132030,2002","DOI":"10.1002\/1521-4141(200207)32:7<2021::AID-IMMU2021>3.0.CO;2-J"}],"container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/52\/8\/1976\/375028\/db0803001976.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/52\/8\/1976\/375028\/db0803001976.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T21:52:56Z","timestamp":1683755576000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/52\/8\/1976\/13831\/Prevention-of-Diabetes-in-NOD-Mice-by"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8,1]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2003,8,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diabetes.52.8.1976","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,8,1]]}}}