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In the second phase, nitrergic degeneration takes place in the cell bodies in the ganglia, leading to complete loss of nitrergic function. The changes in the first phase are reversible with insulin replacement; however, the neurodegeneration in the second phase is irreversible. Neurodegeneration is due to apoptotic cell death in the ganglia, which is selective for the nitrergic neurones.<\/jats:p>","DOI":"10.2337\/diabetes.52.9.2353","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T14:04:22Z","timestamp":1173189862000},"page":"2353-2362","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":155,"title":["Two Phases of Nitrergic Neuropathy in Streptozotocin-Induced Diabetic Rats"],"prefix":"10.2337","volume":"52","author":[{"given":"Selim","family":"Cellek","sequence":"first","affiliation":[{"name":"From the Wolfson Institute for Biomedical Research, University College London, London, U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neale A.","family":"Foxwell","sequence":"additional","affiliation":[{"name":"From the Wolfson Institute for Biomedical Research, University College London, London, U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Moncada","sequence":"additional","affiliation":[{"name":"From the Wolfson Institute for Biomedical Research, University College London, London, U.K"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031207321014400_R1","doi-asserted-by":"crossref","unstructured":"Greene DA, Lattimer S, Ulbrecht J, Carroll P: Glucose-induced alterations in nerve metabolism: current perspective on the pathogenesis of diabetic neuropathy and future directions for research and therapy. 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