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Association of CCAAT\/enhancer-binding protein \u03b1 (a positive regulator of the resistin gene) and its coactivators p300, cAMP response element-binding protein binding protein, and retinoblastoma protein with the resistin gene promoter was reduced in RA-treated adipocytes. RA administration to normal mice resulted in reduced resistin mRNA levels in brown and white adipose tissues, reduced circulating resistin levels, reduced body weight, and improved glucose tolerance. Resistin expression was also downregulated after dietary vitamin A supplementation in mice. The results raise the possibility that vitamin A status may contribute to modulate systemic functions through effects on the production of adipocyte-derived protein signals.<\/jats:p>","DOI":"10.2337\/diabetes.53.4.882","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:04:22Z","timestamp":1173207862000},"page":"882-889","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":110,"title":["Modulation of Resistin Expression by Retinoic Acid and Vitamin A Status"],"prefix":"10.2337","volume":"53","author":[{"given":"Francisco","family":"Felipe","sequence":"first","affiliation":[{"name":"From the Laboratory of Molecular Biology, Nutrition and Biotechnology, Department of Fundamental Biology and Health Sciences, University of the Balearic Islands, Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Luisa","family":"Bonet","sequence":"additional","affiliation":[{"name":"From the Laboratory of Molecular Biology, Nutrition and Biotechnology, Department of Fundamental Biology and Health Sciences, University of the Balearic Islands, Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Ribot","sequence":"additional","affiliation":[{"name":"From the Laboratory of Molecular Biology, Nutrition and Biotechnology, Department of Fundamental Biology and Health Sciences, University of the Balearic Islands, Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreu","family":"Palou","sequence":"additional","affiliation":[{"name":"From the Laboratory of Molecular Biology, Nutrition and Biotechnology, Department of Fundamental Biology and Health Sciences, University of the Balearic Islands, Palma de Mallorca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1167","reference":[{"key":"2022031217022857100_R1","doi-asserted-by":"crossref","unstructured":"Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA: The hormone resistin links obesity to diabetes. 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