{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:53:17Z","timestamp":1770745997556,"version":"3.49.0"},"reference-count":54,"publisher":"American Diabetes Association","issue":"9","content-domain":{"domain":["diabetesjournals.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2004,9,1]]},"abstract":"<jats:p>To evaluate the effects of kidney-pancreas transplantation on hemostatic abnormalities in uremic type 1 diabetic patients, we conducted a cross-sectional study involving 12 type 1 diabetic patients, 30 uremic type 1 diabetic patients, 27 uremic type 1 diabetic patients who had a kidney-pancreas transplant, 12 uremic type 1 diabetic patients who had a kidney-alone transplant, and 13 healthy control subjects. We evaluated platelet and clotting system. Platelets in the group of uremic type 1 diabetic patients were significantly larger than platelets in the other groups. Resting calcium levels were significantly higher in the uremic type 1 diabetic patients and uremic type 1 diabetic patients who had a kidney-alone transplant than in the type 1 diabetic patients who had a kidney-pancreas transplant and control subjects. CD41 expression was significantly reduced in platelets from the uremic type 1 diabetic patients compared with the other groups. Levels of hypercoagulability markers in the type 1 diabetic patients who had a kidney-pancreas transplant and, to a lesser extent, the uremic type 1 diabetic patients who had a kidney-alone transplant but not the uremic type 1 diabetic patients were similar to those of the control subjects. A reduction in natural anticoagulants was evident in the uremic type 1 diabetic patients, whereas near-normal values were observed in the type 1 diabetic patients who had a kidney-pancreas transplant and uremic type 1 diabetic patients who had a kidney-alone transplant. Hemostatic abnormalities were not observed in type 1 diabetic patients who had a kidney-pancreas transplant. This finding might explain the lower cardiovascular death rate observed in type 1 diabetic patients who had a kidney-pancreas transplant compared with uremic type 1 diabetic patients who had a kidney-alone transplant or uremic type 1 diabetic patients.<\/jats:p>","DOI":"10.2337\/diabetes.53.9.2291","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:04:22Z","timestamp":1173207862000},"page":"2291-2300","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":15,"title":["Normalization of Multiple Hemostatic Abnormalities in Uremic Type 1 Diabetic Patients After Kidney-Pancreas Transplantation"],"prefix":"10.2337","volume":"53","author":[{"given":"Paolo","family":"Fiorina","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Folli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"D\u2019Angelo","sequence":"additional","affiliation":[{"name":"Coagulation Service and Thrombosis, Research Unit, San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanna","family":"Finzi","sequence":"additional","affiliation":[{"name":"Pathology Department, Universita\u0300 dell\u2019Insubria, Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Pellegatta","sequence":"additional","affiliation":[{"name":"Istituto di Farmacologia, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeria","family":"Guzzi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Fedeli","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia Della","family":"Valle","sequence":"additional","affiliation":[{"name":"Coagulation Service and Thrombosis, Research Unit, San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana","family":"Usellini","sequence":"additional","affiliation":[{"name":"Pathology Department, Universita\u0300 dell\u2019Insubria, Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Placidi","sequence":"additional","affiliation":[{"name":"Pathology Department, Universita\u0300 dell\u2019Insubria, Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bifari","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Belloni","sequence":"additional","affiliation":[{"name":"Institute of General Pathology, University of Milan, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Ferrero","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, San Raffaele Scientific Institute, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Capella","sequence":"additional","affiliation":[{"name":"Pathology Department, Universita\u0300 dell\u2019Insubria, Varese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Secchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, San Raffaele Scientific Institute, Milan, Italy"},{"name":"Universita\u2019 Vita e Salute-San Raffaele, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1167","reference":[{"key":"2022031209002275100_R1","doi-asserted-by":"crossref","unstructured":"Rauch U, Ziegler D, Piolot R, Schwippert B, Benthake H, Schultheiss HP, Tschoepe D: Platelet activation in diabetic cardiovascular autonomic neuropathy. Diabet Med\u200816:848\u2013852,1999","DOI":"10.1046\/j.1464-5491.1999.00160.x"},{"key":"2022031209002275100_R2","doi-asserted-by":"crossref","unstructured":"Rink TJ, Sage SO: Calcium signaling in human platelets. Annu Rev Physiol\u200852:431\u2013449,1990","DOI":"10.1146\/annurev.ph.52.030190.002243"},{"key":"2022031209002275100_R3","doi-asserted-by":"crossref","unstructured":"Vicari AM, Taglietti MV, Pellegatta F, Spotti D, Melandri M, Galli L, Ronchi P, Folli F: Deranged platelet calcium homeostasis in diabetic patients with end-stage renal failure: a possible link to increased cardiovascular mortality?Diabetes Care\u200819:1062\u20131066,1996","DOI":"10.2337\/diacare.19.10.1062"},{"key":"2022031209002275100_R4","doi-asserted-by":"crossref","unstructured":"Winocour PD: Platelet abnormalities in diabetes mellitus. Diabetes\u200841:26\u201329,1992","DOI":"10.2337\/diabetes.41.1.26"},{"key":"2022031209002275100_R5","doi-asserted-by":"crossref","unstructured":"Mustard JF, Packham MA: Platelets and diabetes mellitus. N Engl J Med\u2008311:665\u2013667,1984","DOI":"10.1056\/NEJM198409063111010"},{"key":"2022031209002275100_R6","doi-asserted-by":"crossref","unstructured":"Matsubara Y, Murata M, Maruyama T, Handa M, Yamagata N, Watanabe G, Saruta T, Ikeda Y: Association between diabetic retinopathy and genetic variations in \u03b12\u03b21 integrin, a platelet receptor for collagen. Blood\u200895:1560\u20131564,2000","DOI":"10.1182\/blood.V95.5.1560.005k43_1560_1564"},{"key":"2022031209002275100_R7","doi-asserted-by":"crossref","unstructured":"Dallinger KJ, Jennings PE, Toop MJ, Clyde OH, Barnett AH: Platelet aggregation and coagulation factors in insulin dependent diabetes with and without microangiopathy. Diabet Med\u20084:44\u201348,1987","DOI":"10.1111\/j.1464-5491.1987.tb00827.x"},{"key":"2022031209002275100_R8","doi-asserted-by":"crossref","unstructured":"Pape AL, Gutman N, Guitton JD, Legrand Y, Muh JP: Non enzymatic glycosylation increases platelet aggregating potency of collagen from placenta of diabetic human beings. Biochem Biophys Res Commun\u2008111:602\u2013610,1983","DOI":"10.1016\/0006-291X(83)90349-2"},{"key":"2022031209002275100_R9","doi-asserted-by":"crossref","unstructured":"Tschoepe D, Driesch E, Schwippert B, Nieuwenhuis HK, Gries FA: Exposure of adhesion molecules on activated platelets in patients with newly diagnosed IDDM is not normalized by near-normoglycemia. Diabetes\u200844:890\u2013894,1995","DOI":"10.2337\/diabetes.44.8.890"},{"key":"2022031209002275100_R10","doi-asserted-by":"crossref","unstructured":"Remuzzi G: Bleeding in renal failure. Lancet\u20081:1205\u20131208,1988","DOI":"10.1016\/S0140-6736(88)92019-3"},{"key":"2022031209002275100_R11","doi-asserted-by":"crossref","unstructured":"Diabetes mellitus: a major risk factor for cardiovascular disease: a joint editorial statement. Circulation\u2008100:1132\u20131133,1999","DOI":"10.1161\/01.CIR.100.10.1132"},{"key":"2022031209002275100_R12","doi-asserted-by":"crossref","unstructured":"Nathan DM: Long-term complications of diabetes mellitus. N Engl J Med\u2008328:1676\u20131685,1993","DOI":"10.1056\/NEJM199306103282306"},{"key":"2022031209002275100_R13","doi-asserted-by":"crossref","unstructured":"Joint Working Party on Diabetic Renal Failure: Renal failure in the UK: deficient provision of care in 1985. Diabet Med\u20085:79\u201384,1988","DOI":"10.1111\/j.1464-5491.1988.tb00947.x"},{"key":"2022031209002275100_R14","doi-asserted-by":"crossref","unstructured":"Ross R: Atherosclerosis\u2014an inflammatory disease. N Engl J Med\u2008340:115\u2013126,1999","DOI":"10.1056\/NEJM199901143400207"},{"key":"2022031209002275100_R15","doi-asserted-by":"crossref","unstructured":"Aso Y, Inukai T, Takemura Y: Mechanisms of elevation of serum and urinary concentrations of soluble thrombomodulin in diabetic patients: possible application as a marker for vascular endothelial injury. Metabolism\u200847:362\u2013365,1998","DOI":"10.1016\/S0026-0495(98)90272-4"},{"key":"2022031209002275100_R16","unstructured":"Higgins RM, Gray DW, Morris PJ: Association of thrombosis after renal transplantation with elevation of the platelet count. Transplantation\u200859:1353\u20131355,1995"},{"key":"2022031209002275100_R17","doi-asserted-by":"crossref","unstructured":"Tschope D, Schwippert B, Schettler B, Kiesel U, Rothe H, Roesen P, Gries FA: Increased GPIIB\/IIIA expression and altered DNA-ploidy pattern in megakaryocytes of diabetic BB-rats. Eur J Clin Invest\u200822:591\u2013598,1992","DOI":"10.1111\/j.1365-2362.1992.tb01510.x"},{"key":"2022031209002275100_R18","doi-asserted-by":"crossref","unstructured":"Mazzanti L, Rabini RA, Fumelli P, Martarelli D, Staffolani R, Salvolini E, Curatola G: Altered platelet membrane dynamic properties in type 1 diabetes. Diabetes\u200846:2069\u20132074,1997","DOI":"10.2337\/diabetes.46.12.2069"},{"key":"2022031209002275100_R19","doi-asserted-by":"crossref","unstructured":"Winkler J, Fuchs J, Morduchowicz G, Boner G, Sulkiss J, Weinberger I: Circulating aggregated platelets, number of platelets per aggregate and platelet size in chronic dialysis patients. Nephron\u200877:44\u201347,1997","DOI":"10.1159\/000190245"},{"key":"2022031209002275100_R20","doi-asserted-by":"crossref","unstructured":"Bath PM, Butterworth RJ: Platelet size: measurement, physiology and vascular disease. Blood Coagul Fibrinolysis\u20087:157\u2013161,1996","DOI":"10.1097\/00001721-199603000-00011"},{"key":"2022031209002275100_R21","doi-asserted-by":"crossref","unstructured":"Tschoepe D, Roesen P, Esser J, Schwippert B, Nieuwenhuis HK, Kehrel B, Gries FA: Large platelets circulate in an activated state in diabetes mellitus. Semin Thromb Hemost\u200817:433\u2013438,1991","DOI":"10.1055\/s-2007-1002650"},{"key":"2022031209002275100_R22","doi-asserted-by":"crossref","unstructured":"Cagliero E, Porta M, Cousins S, Kohner EM: Increased platelet volume in diabetic retinopathy. Hemostasis\u200812:293\u2013299,1982","DOI":"10.1159\/000214686"},{"key":"2022031209002275100_R23","doi-asserted-by":"crossref","unstructured":"Tschoepe D, Driesch E, Schwippert B, Lampeter EF, DENIS Study Group: Activated platelets in subjects at increased risk of IDDM. Diabetologia\u200840:573\u2013577,1997","DOI":"10.1007\/s001250050717"},{"key":"2022031209002275100_R24","doi-asserted-by":"crossref","unstructured":"Ishihara H, Connolly AJ, Zeng D, Kahn ML, Zheng YW, Timmons C, Tram T, Coughlin SR: Protease-activated receptor 3 is a second thrombin receptor in humans. Nature\u2008386:502\u2013506,1997","DOI":"10.1038\/386502a0"},{"key":"2022031209002275100_R25","doi-asserted-by":"crossref","unstructured":"Ishihara H, Zeng D, Connolly AJ, Tam C, Coughlin SR: Antibodies to protease-activated receptor 3 inhibit activation of mouse platelets by thrombin. Blood\u200891:4152\u20134157,1998","DOI":"10.1182\/blood.V91.11.4152"},{"key":"2022031209002275100_R26","doi-asserted-by":"crossref","unstructured":"Vicari AM, Monzani ML, Pellegatta F, Ronchi P, Galli L, Folli F: Platelet calcium homeostasis is abnormal in patients with severe arteriosclerosis. Arterioscler Thromb\u200814:1420\u20131424,1994","DOI":"10.1161\/01.ATV.14.9.1420"},{"key":"2022031209002275100_R27","doi-asserted-by":"crossref","unstructured":"Eggers PW: Effects of transplantation on the Medicare end-stage renal disease program. N Engl J Med\u2008318:223\u2013229,1988","DOI":"10.1056\/NEJM198801283180406"},{"key":"2022031209002275100_R28","doi-asserted-by":"crossref","unstructured":"Secchi A, Caldara R, La Rocca E, Fiorina P, Di Carlo V: Cardiovascular disease and neoplasm after pancreas transplantation. Lancet\u2008352:9121,1998","DOI":"10.1016\/S0140-6736(05)79546-5"},{"key":"2022031209002275100_R29","doi-asserted-by":"crossref","unstructured":"Tyden G, Bolinder J, Solders G, Brattstrom C, Tibell A, Groth CG: Improved survival in patients with insulin-dependent diabetes mellitus and end-stage diabetic nephropathy 10 years after combined pancreas and kidney transplantation. Transplantation\u20085:645\u2013648,1999","DOI":"10.1097\/00007890-199903150-00001"},{"key":"2022031209002275100_R30","doi-asserted-by":"crossref","unstructured":"Sung RS, Althoen M, Howell TA, Merion RM: Peripheral vascular occlusive disease in renal transplant recipients: risk factors and impact on kidney allograft survival. Transplantation\u200870:1049\u20131054,2000","DOI":"10.1097\/00007890-200010150-00010"},{"key":"2022031209002275100_R31","doi-asserted-by":"crossref","unstructured":"La Rocca E, Fiorina P, Di Carlo V, Astorri E, Rossetti C, Lucignani G, Fazio F, Giudici D, Cristallo M, Bianchi G, Pozza G, Secchi A: Cardiovascular outcomes after kidney-pancreas and kidney-alone transplantation. Kidney Int\u200860:1964\u20131971,2001","DOI":"10.1046\/j.1523-1755.2001.00008.x"},{"key":"2022031209002275100_R32","doi-asserted-by":"crossref","unstructured":"Fiorina P, La Rocca E, Venturini M, Minicucci F, Fermo I, Paroni R, D\u2019Angelo A, Sblendido M, Di Carlo V, Cristallo M, Del Maschio A, Pozza G, Secchi A: Effects of kidney-pancreas transplantation on atherosclerotic risk factors and endothelial function in patients with uremia and type 1 diabetes. Diabetes\u200850:496\u2013501,2001","DOI":"10.2337\/diabetes.50.3.496"},{"key":"2022031209002275100_R33","doi-asserted-by":"crossref","unstructured":"Fiorina P, Folli F, Bertuzzi F, Maffi P, Finzi G, Venturini M, Socci C, Davalli A, Orsenigo E, Monti L, Falqui L, Uccella S, La Rosa S, Usellini L, Properzi G, Di Carlo V, Del Maschio A, Capella C, Secchi A: Long-term beneficial effect of islet transplantation on diabetic macro-\/microangiopathy in type 1 diabetic kidney-transplanted patients. Diabetes Care\u200826:1129\u20131136,2003","DOI":"10.2337\/diacare.26.4.1129"},{"key":"2022031209002275100_R34","doi-asserted-by":"crossref","unstructured":"Fiorina P, Folli F, Maffi P, Placidi C, Venturini M, Finzi G, Bertuzzi F, Davalli A, D\u2019Angelo A, Socci C, Gremizzi C, Orsenigo E, La Rosa S, Ponzoni M, Cardillo M, Scalamogna M, Del Maschio A, Capella C, Di Carlo V, Secchi A: Islet transplantation improves vascular diabetic complications in patients with diabetes who underwent kidney transplantation: a comparison between kidney-pancreas and kidney-alone transplantation. Transplantation\u200875:1296\u20131301,2003","DOI":"10.1097\/01.TP.0000061788.32639.D9"},{"key":"2022031209002275100_R35","doi-asserted-by":"crossref","unstructured":"Wyant TL, Smith PC, Brown B, Kantor AB: Whole blood microvolume laser scanning cytometry for monitoring resting and activated platelets. Platelets\u200812:309\u2013318,2001","DOI":"10.1080\/09537100120068206"},{"key":"2022031209002275100_R36","doi-asserted-by":"crossref","unstructured":"Zucker-Franklin D, Kaushansky K: Effect of thrombopoietin on the development of megakaryocytes and platelets: an ultrastructural analysis. Blood\u200888:1632\u20131638,1996","DOI":"10.1182\/blood.V88.5.1632.bloodjournal8851632"},{"key":"2022031209002275100_R37","unstructured":"D\u2019Angelo A, Della Valle P, Crippa L, Fattorini A, Pattarini E, Vigano D\u2019Angelo S: Relationship between international normalized ratio values, vitamin K-dependent clotting factor levels and in vivo prothrombin activation during the early and steady phases of oral anticoagulant treatment. Haematologica\u200887:1074\u20131080,2002"},{"key":"2022031209002275100_R38","doi-asserted-by":"crossref","unstructured":"Vigano D\u2019Angelo S, Comp PC, Esmon CT, D\u2019Angelo A: Relationship between protein C antigen and anticoagulant activity during oral anticoagulation and in selected disease states. J Clin Invest\u200877:416\u2013425,1986","DOI":"10.1172\/JCI112319"},{"key":"2022031209002275100_R39","doi-asserted-by":"crossref","unstructured":"Vigano\u0300 D\u2019Angelo S, Tombesi S, Marcovina S, Albertini A, Della Valle P, D\u2019Angelo A: Monoclonal antibody-based enzyme-linked immunosorbent assays (ELISA) for measurement of vitamin K-dependent protein S: the effect of antibody immunoreactivity on plasma protein S antigen determinations. Thromb Haemost\u200867:631\u2013638,1992","DOI":"10.1055\/s-0038-1648514"},{"key":"2022031209002275100_R40","doi-asserted-by":"crossref","unstructured":"Volpato S, Pahor M, Ferrucci L, Simonsick EM, Guralnik JM, Kritchevsky SB, Fellin R, Harris TB: Relationship of alcohol intake with inflammatory markers and plasminogen activator inhibitor-1 in well-functioning older adults: the Health, Aging, and Body Composition study. Circulation\u2008109:607\u2013612,2004","DOI":"10.1161\/01.CIR.0000109503.13955.00"},{"key":"2022031209002275100_R41","doi-asserted-by":"crossref","unstructured":"Ma LJ, Mao SL, Taylor KL, Kanjanabuch T, Guan Y, Zhang Y, Brown NJ, Swift LL, McGuinness OP, Wasserman DH, Vaughan DE, Fogo AB: Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1. Diabetes\u200853:336\u2013346,2004","DOI":"10.2337\/diabetes.53.2.336"},{"key":"2022031209002275100_R42","doi-asserted-by":"crossref","unstructured":"Wolfe RA, Ashby VB, Milford EL, Ojo AO, Ettenger RE, Agodoa LYC, Held PJ, Port FK: Comparison of mortality in all patients on dialysis, patients on dialysis awaiting transplantation, and recipients of a first cadaveric transplant. N Engl J Med\u2008341:1725\u20131730,1999","DOI":"10.1056\/NEJM199912023412303"},{"key":"2022031209002275100_R43","doi-asserted-by":"crossref","unstructured":"Smets YF, Westendorp RG, van der Pijl JW, de Charro FT, Ringers J, de Fijter JW, Lemkes HH: Effect of simultaneous pancreas-kidney transplantation on mortality of patients with type-1 diabetes mellitus and end-stage renal failure. Lancet\u2008353:1915\u20131919,1999","DOI":"10.1016\/S0140-6736(98)07513-8"},{"key":"2022031209002275100_R44","doi-asserted-by":"crossref","unstructured":"Moal V, Brunet P, Dou L, Morange S, Sampol J, Berland Y: Impaired expression of glycoproteins on resting and stimulated platelets in uraemic patients. Nephrol Dial Transplant\u200818:1834\u20131841,2003","DOI":"10.1093\/ndt\/gfg185"},{"key":"2022031209002275100_R45","doi-asserted-by":"crossref","unstructured":"Sreedhara R, Itagaki I, Hakim RM: Uremic patients have decreased shear-induced platelet aggregation mediated by decreased availability of glycoprotein IIb-IIIa receptors. Am J Kidney Dis\u200827:355\u2013364,1996","DOI":"10.1016\/S0272-6386(96)90358-3"},{"key":"2022031209002275100_R46","doi-asserted-by":"crossref","unstructured":"Fellstrom B, Siegbahn A, Liljenberg G, Haglund O, Wallin R, Tufveson G, Bagge L: Primary haemostasis, plasmatic coagulation and fibrinolysis in renal transplantation. Thromb Res\u200859:97\u2013104,1990","DOI":"10.1016\/0049-3848(90)90275-H"},{"key":"2022031209002275100_R47","doi-asserted-by":"crossref","unstructured":"Mezzano D, Tagle R, Panes O, Perez M, Downey P, Munoz B, Aranda E, Barja P, Thambo S, Gonzalez F, Mezzano S, Pereira J: Hemostatic disorder of uremia: the platelet defect, main determinant of the prolonged bleeding time, is correlated with indices of activation of coagulation and fibrinolysis. Thromb Haemost\u200876:312\u2013321,1996","DOI":"10.1055\/s-0038-1650576"},{"key":"2022031209002275100_R48","doi-asserted-by":"crossref","unstructured":"Smith FB, Rumley A, Lee AJ, Leng GC, Fowkes FG, Lowe GD: Haemostatic factors and prediction of ischaemic heart disease and stroke in claudicants. Br J Haematol.\u2008100:758\u2013763,1998","DOI":"10.1046\/j.1365-2141.1998.00626.x"},{"key":"2022031209002275100_R49","doi-asserted-by":"crossref","unstructured":"Rabini RA, Staffolani R, Fumelli P, Mutus B, Curatola G, Mazzanti L: Decreased nitric oxide synthase activity in platelets from IDDM and NIDDM patients. Diabetologia\u200841:101\u2013104,1998","DOI":"10.1007\/s001250050873"},{"key":"2022031209002275100_R50","doi-asserted-by":"crossref","unstructured":"Martina V, Bruno GA, Trucco F, Zumpano E, Tagliabue M, Di Bisceglie C, Pescarmona G: Platelet cNOS activity is reduced in patients with IDDM and NIDDM. Thromb Haemost\u200879:520\u2013522,1998","DOI":"10.1055\/s-0037-1614937"},{"key":"2022031209002275100_R51","doi-asserted-by":"crossref","unstructured":"Loscalzo J: Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circ Res\u200888:756\u2013762,2001","DOI":"10.1161\/hh0801.089861"},{"key":"2022031209002275100_R52","doi-asserted-by":"crossref","unstructured":"Pigazzi A, Heydrick S, Folli F, Benoit S, Michelson A, Loscalzo J: Nitric oxide inhibits thrombin receptor-activating peptide-induced phosphoinositide 3-kinase activity in human platelets. J Biol Chem\u2008274:14368\u201314375,1999","DOI":"10.1074\/jbc.274.20.14368"},{"key":"2022031209002275100_R53","doi-asserted-by":"crossref","unstructured":"Ceriello A, Giacomello R, Stel G, Motz E, Taboga C, Tonutti L, Pirisi M, Falleti E, Bartoli E: Hyperglycemia-induced thrombin formation in diabetes: the possible role of oxidative stress. Diabetes\u200844:924\u2013928,1995","DOI":"10.2337\/diab.44.8.924"},{"key":"2022031209002275100_R54","doi-asserted-by":"crossref","unstructured":"Kario K, Matsuo T, Yamada T, Nakao K, Shimano C, Matsuo M: Factor VII hyperactivity in chronic dialysis patients. Thromb Res\u200867:105\u2013113,1992","DOI":"10.1016\/0049-3848(92)90262-9"}],"container-title":["Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.org\/diabetes\/diabetes\/article-pdf\/53\/9\/2291\/654063\/zdb00904002291.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article-pdf\/53\/9\/2291\/654063\/zdb00904002291.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T16:23:10Z","timestamp":1667406190000},"score":1,"resource":{"primary":{"URL":"https:\/\/diabetesjournals.org\/diabetes\/article\/53\/9\/2291\/14685\/Normalization-of-Multiple-Hemostatic-Abnormalities"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9,1]]},"references-count":54,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,9,1]]}},"URL":"https:\/\/doi.org\/10.2337\/diabetes.53.9.2291","relation":{},"ISSN":["0012-1797","1939-327X"],"issn-type":[{"value":"0012-1797","type":"print"},{"value":"1939-327X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,9,1]]}}}