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PCOS women with normal glucose tolerance (81.8%) were subdivided into two groups: those who were overweight or obese and those of normal weight. Metabolic and hormonal characteristics of the GI group included significantly higher fasting and glucose-stimulated insulin levels, more severe insulin resistance, hyperandrogenemia, and significantly higher cortisol and androstenedione responses to 1\u201324 ACTH stimulation. One important finding was that lower birth weight and earlier age of menarche were associated with GI in PCOS women. Frequency of hirsutism, oligomenorrhea, acne, and acanthosis nigricans did not characterize women with GI. Our findings indicate that PCOS patients with GI represent a subgroup with specific clinical and hormonal characteristics. Our observations may have an important impact in preventative and therapeutic strategies.<\/jats:p>","DOI":"10.2337\/diabetes.53.9.2353","type":"journal-article","created":{"date-parts":[[2007,3,6]],"date-time":"2007-03-06T19:04:22Z","timestamp":1173207862000},"page":"2353-2358","update-policy":"https:\/\/doi.org\/10.2337\/ada-journal-policies","source":"Crossref","is-referenced-by-count":124,"title":["Glucose Intolerance in a Large Cohort of Mediterranean Women With Polycystic Ovary Syndrome"],"prefix":"10.2337","volume":"53","author":[{"given":"Alessandra","family":"Gambineri","sequence":"first","affiliation":[{"name":"From the Division of Endocrinology, Department of Internal Medicine and Gastroenterology, S. 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Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Cacciari","sequence":"additional","affiliation":[{"name":"From the Division of Endocrinology, Department of Internal Medicine and Gastroenterology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Maria","family":"Morselli-Labate","sequence":"additional","affiliation":[{"name":"From the Division of Endocrinology, Department of Internal Medicine and Gastroenterology, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uberto","family":"Pagotto","sequence":"additional","affiliation":[{"name":"From the Division of Endocrinology, Department of Internal Medicine and Gastroenterology, S. 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